Differential Expression of Kv1.3 and Kv1.5 Voltage-Dependent K+Channels in Human Skeletal Muscle Sarcomas
| Autor: | Antonio Felipe, Santiago Ramón y Cajal, E. Condom, Javier Hernández-Losa, Joanna Bielanska, Joan Carles Ferreres, Rosa Somoza, Teresa Moliné |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adolescent medicine.disease_cause complex mixtures Kv1.5 Potassium Channel Internal medicine Rhabdomyosarcoma medicine Humans natural sciences Differential expression Child Muscle Skeletal Aged K channels Kv1.3 Potassium Channel urogenital system Chemistry G1 Phase Skeletal muscle General Medicine Middle Aged Immunohistochemistry Potassium channel Cell biology Endocrinology medicine.anatomical_structure nervous system Oncology Child Preschool Female biological phenomena cell phenomena and immunity Carcinogenesis |
| Zdroj: | Cancer Investigation. 30:203-208 |
| ISSN: | 1532-4192 0735-7907 |
| DOI: | 10.3109/07357907.2012.654872 |
| Popis: | Because Kv1.3 and Kv1.5 K(+) channels are remodeled during tumorigenesis and participate in skeletal muscle proliferation, we analyzed their expression in human skeletal muscle sarcomas. Aggressive alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS) were studied. Kv1.5 expression was moderate in adult muscle and low in ERMS, whereas it was notable in ARMS and embryonic samples. Kv1.3 expression showed no major differences between RMS and healthy samples. We found a correlation of Kv1.3 and Kv1.5 expression with the tumor malignancy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |