Antiparasitic properties of leaf extracts derived from selected Nicotiana species and Nicotiana tabacum varieties
| Autor: | Sandra Schorderet Weber, Julia Hoeng, Patrice Leroy, Kacper Piotr Kaminski, Jean-Luc Perret, Anatoly Mazurov, Nikolai V. Ivanov, Manuel C. Peitsch |
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| Rok vydání: | 2019 |
| Předmět: |
Nornicotine
Insecta Nematoda Rhipicephalus sanguineus Nicotiana tabacum Toxicology 03 medical and health sciences chemistry.chemical_compound Ticks 0404 agricultural biotechnology Tobacco parasitic diseases Animals 030304 developmental biology Nicotiana 0303 health sciences Antiparasitic Agents biology Traditional medicine Plant Extracts fungi Ricinus Anabasine 04 agricultural and veterinary sciences General Medicine biology.organism_classification 040401 food science Plant Leaves chemistry Lucilia cuprina Biological Assay Female Food Science Anatabine |
| Zdroj: | Food and Chemical Toxicology. 132:110660 |
| ISSN: | 0278-6915 |
| Popis: | Within the traditional pharmacopeia, tobacco (Nicotiana spp.) is often cited as an efficient pesticide. This activity is generally attributed to nicotine, but tobacco plants contain other alkaloids that could potentially contribute to this effect. In this study, we tested methanolic extracts of N. glutinosa, N. glauca, N. debneyi, and N. tabacum (putrescine N-methyltransferase line, burley TN90 and Stella, Virginia ITB 683 and K326), selected according to alkaloid content. Their antiparasitic activity was evaluated in bioassays against adult fleas (Ctenocephalides felis), blowfly (Lucilia cuprina) larvae, nematodes (Caenorhabditis elegans), and ticks (Rhipicephalus sanguineus larvae and adults, Ixodes ricinus nymphs). None of the extracts killed fleas and blowfly larvae effectively at the concentrations tested. Only N. tabacum K326 and N. glutinosa exhibited moderate anthelmintic activity. All extracts significantly repelled R. sanguineus ticks, but not I. ricinus, and the nicotine-rich extracts rapidly knocked down all tick species and stages at high concentrations. The link between nicotine and tick knockdown was confirmed by successfully testing the pure alkaloid at concentrations found in the tobacco extracts. In contrast, repellent activity could not be correlated to the individually tested alkaloids (nicotine, nornicotine, anabasine, anatabine), although anatabine and nornicotine were active in the tick bioassay at high concentrations. |
| Databáze: | OpenAIRE |
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