Prospective study of physical activity and the risk of ovarian cancer
| Autor: | Albert R. Hollenbeck, Steven C. Moore, Corinna Koebnick, James V. Lacey, Louise A. Brinton, Kim N. Danforth, Arthur Schatzkin, Michael F. Leitzmann |
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| Rok vydání: | 2008 |
| Předmět: |
Oncology
endocrine system Cancer Research medicine.medical_specialty endocrine system diseases Physical activity Motor Activity Article Cohort Studies Risk Factors Internal medicine Epidemiology medicine Humans Prospective Studies Prospective cohort study Aged Ovarian Neoplasms Hematology business.industry food and beverages Cancer Middle Aged medicine.disease female genital diseases and pregnancy complications Female Ovarian cancer business Risk assessment Cohort study |
| Zdroj: | Cancer Causes & Control. 20:765-773 |
| ISSN: | 1573-7225 0957-5243 |
| Popis: | Available studies on physical activity and ovarian cancer have produced inconsistent findings, with some previous studies reporting a positive association between vigorous physical activity and ovarian cancer risk.We prospectively investigated the relations of self-reported moderate and vigorous physical activity to ovarian cancer in a cohort of 96,216 US women aged 51-72 years at baseline, followed from 1996-1997 to 31 December 2003.During seven years of follow-up, we documented 309 cases of epithelial ovarian carcinoma. In analyses adjusted for age, the relative risks (RRs) of ovarian cancer for individual and joint combinations of moderate and vigorous physical activity such as entirely inactive, neither moderate nor vigorous physical activity, moderate physical activity only, vigorous physical activity only, and both moderate and vigorous physical activity were 0.88, 1.0 (reference), 0.89, 1.05, and 1.08 (95% confidence interval (CI) = 0.81-1.43, respectively. After multivariate adjustment, the relation was essentially unchanged (RR comparing women with both moderate and vigorous physical activity to those with neither moderate nor vigorous physical activity = 1.10; 95% CI = 0.82-1.48). The null association between physical activity and ovarian cancer persisted in subgroups of women as defined by body mass index, parity, oral contraceptive use, menopausal hormone therapy, family history of ovarian cancer, and other variables (all p values for interaction0.05).Neither moderate nor vigorous physical activity showed a statistically significant association with ovarian cancer in this large cohort of women. |
| Databáze: | OpenAIRE |
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