Caffeine protects against memory loss induced by high and non-anxiolytic dose of cannabidiol in adult zebrafish (Danio rerio)

Autor: Régis Junior Antonioli, Antonio Waldo Zuardi, Luiza Reali Nazario, Carla Denise Bonan, Rosane Souza da Silva, Jaime Eduardo Cecílio Hallak, Katiucia Marques Capiotti, José Alexandre de Souza Crippa
Rok vydání: 2015
Předmět:
medicine.medical_treatment
Clinical Biochemistry
Adenosine A2A/drug effects
Pharmacology
Receptor
Adenosine A2A/drug effects
Toxicology
Biochemistry
Adenosine A2 Receptor Antagonists/pharmacology
Avoidance Learning/drug effects
Caffeine/pharmacology
cannabidiol
Behavioral Neuroscience
chemistry.chemical_compound
Behavior
Animal/drug effects
Cannabidiol
Zebrafish
caffeine
Behavior
Animal
Adenosine A1 Receptor Antagonists/pharmacology
Animal/drug effects
Adenosine A2 Receptor Antagonists
surgical procedures
operative
Drug
Psychology
Caffeine
Receptor
medicine.drug
Receptor
Adenosine A2A
medicine.drug_class
Motor Activity/drug effects
CANABINOIDES
Adenosine A1 Receptor Antagonists
Motor Activity
Adenosine receptor antagonist
digestive system
Anxiolytic
Dose-Response Relationship
Adenosine A1 receptor
Memory Disorders/chemically induced
medicine
Avoidance Learning
Animals
Biological Psychiatry
Behavior
Memory Disorders
Dose-Response Relationship
Drug
zebrafish
Adenosine
Adenosine receptor
digestive system diseases
Cannabidiol/antagonists & inhibitors
chemistry
Central Nervous System Stimulants/pharmacology
Central Nervous System Stimulants
Cannabinoid
Zdroj: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Repositório Institucional PUCRS
Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
Pharmacology, Biochemistry and Behavior, 135, 210-6. Elsevier
ISSN: 1873-5177
0091-3057
Popis: Cannabidiol (CBD) has been investigated in a wide spectrum of clinical approaches due to its psychopharmacological properties. CBD has low affinity for cannabinoid neuroreceptors and agonistic properties to 5-HT receptors. An interaction between cannabinoid and purinergic receptor systems has been proposed. The purpose of this study is to evaluate CBD properties on memory behavioral and locomotor parameters and the effects of pre-treatment of adenosine receptor blockers on CBD impacts on memory using adult zebrafish. CBD (0.1, 0.5, 5, and 10mg/kg) was tested in the avoidance inhibitory paradigm and anxiety task. We analyzed the effect of a long-term caffeine pre-treatment (~20mg/L - four months). Also, acute block of adenosine receptors was performed in co-administration with CBD exposure in the memory assessment. CBD promoted an inverted U-shaped dose-response curve in the anxiety task; in the memory assessment, CBD in the dose of 5mg/Kg promoted the strongest effects without interfering with social and aggressive behavior. Caffeine treatment was able to prevent CBD (5mg/kg) effects on memory when CBD was given after the training session. CBD effects on memory were partially prevented by co-treatment with a specific A2A adenosine receptor antagonist when given prior to or after the training session, while CBD effects after the training session were fully prevented by adenosine A1 receptor antagonist. These results indicated that zebrafish have responses to CBD anxiolytic properties that are comparable to other animal models, and high doses changed memory retention in a way dependent on adenosine.
Databáze: OpenAIRE
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