Effects of maternal hypothyroidism in the gastrointestinal system of male young offspring from Wistar rats
Autor: | Lívia Prometti de Rezende, Jéssica Fortunato Silva, Victor Augusto Alves da Costa, Ana Paula Coelho Balbi, Luiz Borges Bispo da Silva |
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Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Litter (animal) Male Offspring Medicine (miscellaneous) Physiology 030209 endocrinology & metabolism 03 medical and health sciences 0302 clinical medicine Maternal hypothyroidism Hypothyroidism Pregnancy Lactation medicine Animals Stomach Ulcer Rats Wistar business.industry Stomach medicine.disease Small intestine Rats 030104 developmental biology medicine.anatomical_structure Animals Newborn Maternal Exposure Gestation Female medicine.symptom business Gastrointestinal Motility Weight gain |
Zdroj: | Journal of developmental origins of health and disease. 12(2) |
ISSN: | 2040-1752 |
Popis: | Alterations in the maternal environment may impact on the fetal development. The objective of this study was to investigate the gastrointestinal consequences of maternal hypothyroidism for the male offspring from Wistar rats. The pregnant rats were divided into three groups: control (C – received water), experimental 1 [E1 – received methimazole (MMI) solution] during gestation and lactation, and experimental 2 (E2 – received MMI solution) during gestation. Maternal parameters evaluated: free T3 and T4, bodyweight variation, and water/food intake. Offspring parameters evaluated: litter size, number of male/female, free T3 and T4, stomach area, gastric ulcer susceptibility, small intestine length and weight, small intestine and distal colon motility, the stomach and intestinal weight–body weight ratio (SW/BW–IW/BW), and the accumulation of intestinal fluid. Maternal T3 and T4 from E1 were decreased when compared to the other groups. There were no differences for maternal water/food intake and weight gain, litter size, and number of males and females. Regarding to offspring, free T3, SW/BW, IW/BW, and intestinal fluid accumulation were not different between the groups, but T4 was decreased in E1. However, 30-day-old pups from E1 and E2 were smaller with lower stomach and small intestine. Even more, E1 presented a lower ulcer index when compared to the C, while E2 had a higher distal colon transit. It can be concluded that maternal hypothyroidism impaired the total body development, as well as gastric and intestinal development, besides interfering with the susceptibility to the ulcer and intestinal transit of male offspring from Wistar rats. |
Databáze: | OpenAIRE |
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