Clinical, Electrocardiographic, and Hemodynamic Effects of ICI 89,406, a New Cardioselective Beta-Adrenoceptor Antagonist with Intrinsic Sympathomimetic Activity, in Patients with Angina Pectoris
| Autor: | Jan P. Roos, Josien E. Schreuder, Pim J. de Feyter, Pirzada A. Majid |
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| Rok vydání: | 1980 |
| Předmět: |
Male
medicine.medical_specialty Cardiac output Adrenergic beta-Antagonists Physical Exertion Hemodynamics Blood Pressure Partial agonist Angina Pectoris Propanolamines Coronary artery disease Angina Electrocardiography Oxygen Consumption Heart Rate Internal medicine Heart rate medicine Humans Cardiac Output Pulmonary wedge pressure Aged Pharmacology business.industry Middle Aged medicine.disease Blood pressure Anesthesia Cardiology Vascular Resistance Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of Cardiovascular Pharmacology. 2:435-444 |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/00005344-198007000-00010 |
| Popis: | ICI 89,406, a new cardioselective beta-adrenoceptor antagonist possessing marked intrinsic sympathomimetic activity, was administered (0.04 mg/kg, i.v.) to 10 patients with stable, uncomplicated, exercise-induced angina pectoris and angiographically proven coronary artery disease. The drug resulted in a significant reduction in heart rate (from 125 +/- 5 to 110 +/- 4/min, p less than 0.001), mean systemic arterial pressure (from 147 +/- 4 to 137 +/- 3 mm Hg, p less than 0.01), and electrocardiographic ST-segment depression (from 1.9 +/- 0.5 to 0.8 +/- 0.3 mm, p less than 0.01) without any change in pulmonary arterial or wedge pressure during submaximal supine leg exercise on a bicycle ergometer. These changes were accompanied by a reduction of cardiac output in 6/10 patients and of the duration of pain in 8/10 patients. At rest, all the hemodynamic parameters remained essentially unchanged in comparison with the control study. These studies indicate that ICI 89,406 produces effective beta-adrenoceptor blockade during exercise in patients with angina pectoris. The partial agonist activity of the drug may be responsible for the minimal circulatory response at rest. |
| Databáze: | OpenAIRE |
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