Novel naphthoquinones from a Streptomyces sp

Autor:	Donald C. Paul, Thomas J. Perun, Palaniappan Kulanthaivel, Matthew D. Belvo, Daniel C. Williams, Robert J. Strobel
Rok vydání:	1999
Předmět:	Magnetic Resonance Spectroscopy Stereochemistry Fractionation Spectrometry Mass Fast Atom Bombardment Streptomyces Gas Chromatography-Mass Spectrometry Residue (chemistry) Drug Discovery cdc25 Phosphatases Enzyme Inhibitors Chromatography High Pressure Liquid Pharmacology chemistry.chemical_classification biology Streptomycetaceae Biological activity biology.organism_classification Enzyme chemistry Fermentation Spectrophotometry Ultraviolet Actinomycetales Protein Tyrosine Phosphatases Cysteine Naphthoquinones
Zdroj:	The Journal of antibiotics. 52(3)
ISSN:	0021-8820
Popis:	Cdc25A assay-guided fractionation of a fermentation broth derived from a Streptomyces sp. resulted in the isolation of four novel naphthoquinones 1-4. Structures of these compounds were deduced by NMR and mass spectrometry. Two of them, 3 and 4, incorporate a modified cysteine residue which is observed for the first time in this class of natural products. Naphthoquinones 1-4 showed weak activity against cdc25A phosphatase.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::624ebfcb6785aba0e43c42360c811a36 https://pubmed.ncbi.nlm.nih.gov/10348040 Zobrazit plný text záznamu