Early fragmentation of polyester urethane sheet neither causes persistent oxidative stress nor alters the outcome of normal tissue healing in rat skin
| Autor: | Thiago César Martins, Andreza Hoepers, Anna Paula Piovezan, Geraldo J. S. Bernardes, Franciane Bobinski, Eduardo Cargnin-Ferreira, Rodrigo d'Eça Neves, Armando José d'Acampora, Luiz Augusto Oliveira Belmonte, Clarissa M. Comim, Sandro M. Sgrott, Daniel Martins |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Polyurethane medicine.medical_treatment Population Polyurethanes Biocompatible Materials Matrix (biology) medicine.disease_cause Prosthesis 03 medical and health sciences 0302 clinical medicine Vascularity Absorbable Implants medicine oxidative stress Animals Rats Wistar lcsh:Science education education.field_of_study Wound Healing Multidisciplinary Chemistry Biomaterial cytokines Rats Polyester Wistar rats Oxidative Stress 030104 developmental biology inflammation 030220 oncology & carcinogenesis Models Animal lcsh:Q Female Implant medicine.symptom Oxidative stress |
| Zdroj: | Anais da Academia Brasileira de Ciências, Issue: ahead, Published: 26 JUL 2018 Anais da Academia Brasileira de Ciências v.90 n.2 suppl.1 2018 Anais da Academia Brasileira de Ciências Academia Brasileira de Ciências (ABC) instacron:ABC Anais da Academia Brasileira de Ciências, Vol 90, Iss 2 suppl 1, Pp 2211-2222 (2018) Anais da Academia Brasileira de Ciências, Volume: 90, Issue: 2 Supplement 1, Pages: 2211-2222, Published: 26 JUL 2018 |
| ISSN: | 1678-2690 |
| Popis: | Silicone breast implant is associated with complications inherent to the surgical procedure. Prosthesis coating with polyurethane, however, commonly reduces the incidence of such complications. In this paper, the authors evaluated the inflammatory histomorphometric profile and oxidative damage associated to the implant of polyester urethane sheets. Forty-eight Wistar rats were divided into Sham or polyester urethane groups (n = 8/group) and underwent a polyester urethane implant in the dorsal skinfold. Tissue samples were collected on days seven, 30, and 90 after surgery and subjected to histomorphometric analysis and biochemical tests. Results were analyzed by one-way ANOVA (p ≤ 0.05). Peri-implant tissue samples exhibited characteristic inflammatory response associated with the biomaterial, with increased vascularization on day seven and augmented levels of IL1-b and TNF-a after 30 days. Peri-implant fibrocystic population was small on day seven, but increased considerably after 90 days. A rise in the carbonyl group levels of skin samples in the polyester urethane group was observed on day seven. Findings suggest that polyester urethane sheets undergo biodegradation at an early stage after implantation, followed by increased vascularity and microencapsulation of biomaterial fragments, without persistent oxidative damage. Fiber arrangement inside the collagen matrix results in a fibrotic scar because of polyester urethane degradation. |
| Databáze: | OpenAIRE |
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