Predicting Transfusion Requirements During Extracorporeal Membrane Oxygenation

Autor: Anneliese Heinz, Werner Streif, Helmuth Tauber, Helmut W. Ott, Corinna Velik-Salchner, Guenter Weigel, Lorin Loacker, Josef Fritz
Rok vydání: 2016
Předmět:
Adult
medicine.medical_specialty
Blood transfusion
medicine.medical_treatment
030204 cardiovascular system & hematology
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Extracorporeal Membrane Oxygenation
030202 anesthesiology
extracorporeal membrane oxygenation (ECMO)
Extracorporeal membrane oxygenation
Medicine
Humans
Blood Transfusion
Platelet activation
Prospective Studies
Prospective cohort study
Aged
Prothrombin time
Creatinine
medicine.diagnostic_test
business.industry
Thrombin
creatinine
Middle Aged
Platelet Activation
prothrombin time
Surgery
surgical procedures
operative
Anesthesiology and Pain Medicine
Respiratory failure
chemistry
Anesthesia
Area Under Curve
transfusion requirement
business
Packed red blood cells
Cardiology and Cardiovascular Medicine
thrombin receptor-activating peptide (TRAP)
whole blood impedance aggregometry
Zdroj: Journal of Cardiothoracic and Vascular Anesthesia. 30(3):692-701
ISSN: 1053-0770
DOI: 10.1053/j.jvca.2016.01.009
Popis: ObjectivePatients requiring extracorporeal membrane oxygenation (ECMO) have a well-known bleeding risk and the potential for experiencing possibly fatal thromboembolic complications. Risk factors and predictors of transfusion requirements during ECMO support remain uncertain. The authors hypothesized that compromised organ function immediately before ECMO support will influence transfusion requirements.DesignA prospective observational study.SettingA tertiary, single-institutional university hospital.ParticipantsThe study included 40 adult patients requiring ECMO for intractable cardiac and respiratory failure between July 2010 and December 2012. Blood samples were taken before initiation of ECMO (baseline), after 24 and 48 hours on ECMO, and 24 hours after termination of ECMO.InterventionsNone.Measurements and Main ResultsIndependent of veno-arterial or veno-venous support, 26% of patients required≥2 packed red blood cells per day (PRBC/d) and 74% of patients required
Databáze: OpenAIRE
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