Multifaceted applications of bile salts in pharmacy: an emphasis on nanomedicine
| Autor: | Yosra S.R. Elnaggar |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
liposomes
Medicine (General) Physicochemical Phenomenon Chemical Phenomena Biophysics Cancer therapy Pharmaceutical Science Bioengineering Pharmacy Nanotechnology Review Biomaterials Bile Acids and Salts Drug Delivery Systems R5-920 Drug Discovery Medicine Humans bilosomes Pharmaceutical sciences Micelles business.industry Organic Chemistry General Medicine size-tunable nanoparticles Nanomedicine Nanoparticles bile salt sense organs Nanocarriers business |
| Zdroj: | International Journal of Nanomedicine, Vol 2015, Iss default, Pp 3955-3971 (2015) International Journal of Nanomedicine |
| ISSN: | 1178-2013 |
| Popis: | Yosra SR Elnaggar Department of Pharmaceutics, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt Abstract: The human body has long provided pharmaceutical science with biomaterials of interesting applications. Bile salts (BSs) are biomaterials reminiscent of traditional surfactants with peculiar structure and self-assembled topologies. In the pharmaceutical field, BSs were employed on the basis of two different concepts. The first concept exploited BSs’ metabolic and homeostatic functions in disease modulation, whereas the second one utilized BSs’ potential to modify drug-delivery characteristics, which recently involved nanotechnology. This review is the first to gather major pharmaceutical applications of BSs from endogenous organotropism up to integration into nanomedicine, with a greater focus on the latter domain. Endogenous applications highlighted the role of BS in modulating hypercholesterolemia and cancer therapy in view of enterohepatic circulation. In addition, recent BS-integrated nanomedicines have been surveyed, chiefly size-tunable cholate nanoparticles, BS-lecithin mixed micelles, bilosomes, probilosomes, and surface-engineered bilosomes. A greater emphasis has been laid on nanosystems for vaccine and cancer therapy. The comparative advantages of BS-integrated nanomedicines over conventional nanocarriers have been noted. Paradoxical effects, current pitfalls, future perspectives, and opinions have also been outlined. Keywords: bile salt, nanomedicine, bilosomes, liposomes, size-tunable nanoparticles |
| Databáze: | OpenAIRE |
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