Developmentally regulated GTP-binding protein 2 ameliorates EAE by suppressing the development of TH17 cells
| Autor: | Nal Ae Yoon, Sang Chul Lee, Byung Ju Lee, Hong Kyung Kim, Dae Kyun Chung, Myoung Seok Ko, Hyo Jeong Kim, Jeong Woo Park, Unn Hwa Lee, Jae Hee Suh, Wha Ja Cho |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Encephalomyelitis Autoimmune Experimental Genotype Transgene Immunology Antigen-Presenting Cells Gene Expression Mice Transgenic Subclass Mice chemistry.chemical_compound GTP-Binding Proteins T-Lymphocyte Subsets medicine Animals Immunology and Allergy Promoter Regions Genetic DEVELOPMENTALLY REGULATED GTP-BINDING PROTEIN Antigen-presenting cell Interleukin 6 biology Interleukin-6 Multiple sclerosis Experimental autoimmune encephalomyelitis NF-kappa B Cell Differentiation NF-κB medicine.disease Molecular biology PPAR gamma chemistry biology.protein Cytokines Th17 Cells Inflammation Mediators Co-Repressor Proteins Protein Binding |
| Zdroj: | Clinical Immunology. 150:225-235 |
| ISSN: | 1521-6616 |
| DOI: | 10.1016/j.clim.2013.12.004 |
| Popis: | Developmentally regulated GTP-binding protein 2 (DRG2) represents a novel subclass of GTP-binding proteins. We here report that transgenic overexpression of DRG2 in mice ameliorates experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). The protective effect of DRG2 in EAE was mediated by the inhibition of the development of TH17 cells. DRG2 enhanced the activity of PPARγ, which led to an inhibition of the nuclear factor kappa B (NF-κB) activity and IL-6 production in antigen presenting cells and an inhibition of the development of TH17 cells. Our results demonstrate that DRG2 is an essential modulator of EAE. |
| Databáze: | OpenAIRE |
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