Tunable performance of manganese oxide nanostructures as MRI contrast agents
| Autor: | Lorena García-Hevia, Francisco Rivadulla, Juan Gallo, M. Fátima Cerqueira, Manuel Bañobre-López |
|---|---|
| Přispěvatelé: | Universidade do Minho |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Nanostructure
Cell Survival media_common.quotation_subject Imaging contrast agents chemistry.chemical_element Contrast Media 02 engineering and technology Manganese 010402 general chemistry 01 natural sciences Redox Catalysis Nuclear magnetic resonance electron spin resonance spectroscopy nanostructures medicine Contrast (vision) Humans magnetic resonance imaging media_common Science & Technology medicine.diagnostic_test manganese dioxide Organic Chemistry Magnetic resonance imaging Oxides General Chemistry 021001 nanoscience & nanotechnology Manganese oxide 0104 chemical sciences 3. Good health Highly sensitive imaging agents Kinetics chemistry Manganese Compounds A549 Cells Magnetic resonance Phase composition Igualdade de género MnO2 0210 nano-technology Oxidation-Reduction |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| Popis: | The development of responsive magnetic resonance imaging contrast agents opens the door to a highly sensitive and specific diagnosis of altered physiological conditions. In this field, manganese dioxide (MnO2) is starting to be a leading contributor due to its susceptibility to conditions relevant to human diseased states, such as cancer. So far, the preclinical application of MnO2 has mainly been in the form of nanosheets, with enhancements of magnetic resonance imaging signals up to 50‐fold upon activation. Herein, we thoroughly investigate, through a simple reaction, a series of MnxOy samples and correlate their phase composition and structure/morphology to the performance as classic/responsive MRI contrast agents in response to redox changes. Signal enhancements as high as 140‐fold were obtained from MnO2 nano‐urchins, and their capability as responsive magnetic resonance imaging contrast agents was demonstrated in vitro. This work was partially supported by POCTEP (Co‐operational Programme for Cross‐border Cooperation Spain‐Portugal), by H2020 under project PANA, grant agreement contract number 686009. J.G. acknowledge the financial support from the Marie Curie COFUND Programme (NanoTRAINforGrowth). F.R. acknowledges the Ministerio de Economía y Competitividad of Spain (Project No. MAT2016‐80762‐R), the Consellería de Cultura, Educación e Ordenación Universitaria (ED431F 2016/008, and Centro singular de investigación de Galicia accreditation 2016–2019, ED431G/09) and the European Regional Development Fund (ERDF). |
| Databáze: | OpenAIRE |
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