Peptide growth factors and their receptors in the vein wall
| Autor: | Krzysztof Sobolewski, Lech Romanowicz, Marta Bruczko-Goralewska, Radosław Kowalewski, Małgorzata Wolańska, Justyna Bączyk |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Receptors Peptide Peptide 030204 cardiovascular system & hematology Fibroblast growth factor General Biochemistry Genetics and Molecular Biology Receptor IGF Type 1 Veins Extracellular matrix 03 medical and health sciences 0302 clinical medicine Western blot Internal medicine Varicose veins medicine Humans Vein Receptor Aged chemistry.chemical_classification Vascular Endothelial Growth Factor Receptor-1 medicine.diagnostic_test business.industry Receptor Transforming Growth Factor-beta Type II General Medicine Metabolism Middle Aged Vascular Endothelial Growth Factor Receptor-2 Endocrinology medicine.anatomical_structure chemistry 030220 oncology & carcinogenesis cardiovascular system Intercellular Signaling Peptides and Proteins medicine.symptom business |
| Zdroj: | Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 67(8) |
| ISSN: | 1708-8267 |
| Popis: | The varicose vein wall remodeling is a very complex process, which is controlled by numerous factors, including peptide growth factors. The aim of the study was to assess a/b FGF, IGF-1, TGF-β1, VEGF-A and their receptors in the vein wall. Varicose vein samples were taken from 24 patients undergoing varicose vein surgery. The control material consisted of vein specimens collected from 12 patients with chronic limb ischemia. Contents of aFGF, bFGF, IGF-I, TGF-β1, VEGF, IGF-1R, VEGF R1 and VEGF R2 were assessed with ELISA method. Protein expression of FGF R1 and TGF-β RII were evaluated with western blot. Increased contents of aFGF, IGF-1 and VEGF-A were found in varicose veins in comparison with normal ones (p0.05). IGF-1 R content was significantly increased in varicose veins (p0.05), whereas VEGF R2 content was significantly increased in varicose veins (p0.05). Demonstrated changes in peptide growth factors and their receptors may disturb metabolism of extracellular matrix in the varicose vein wall and contribute to the development of the disease to its more advanced stages. |
| Databáze: | OpenAIRE |
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