Clinical evaluation of the safety and efficacy of a timosaponin A‐III‐based antiwrinkle agent against skin aging
| Autor: | Young Kyoung Seo, A-Rang Im, Sungwook Chae, Se Hee Cho, Ki Mo Kim, Kyeong Hee O |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Keratinocytes Skin Care Articles Ultraviolet Rays Photoaging Human skin Dermatology Cosmetics Matrix metalloproteinase Pharmacology Skin Aging Cell Line 030207 dermatology & venereal diseases 03 medical and health sciences Anemarrhena asphodeloides 0302 clinical medicine medicine timosaponin A‐III Humans Wrinkle biology integumentary system business.industry skin wrinkle clinical trial Tissue Inhibitor of Metalloproteinases Original Contribution Middle Aged Saponins medicine.disease biology.organism_classification HaCaT 030220 oncology & carcinogenesis Toxicity Cytokines Female Steroids medicine.symptom Matrix Metalloproteinase 1 business |
| Zdroj: | Journal of Cosmetic Dermatology |
| ISSN: | 1473-2165 1473-2130 |
| Popis: | Background Timosaponin A‐III (TA‐III) is known to exist in the medicinal herb of Anemarrhena asphodeloides as one of major chemical components. Aims The photoprotective properties of TA‐III on UVB‐exposed HaCaT cells were evaluated on the antiwrinkle effects and skin safety in terms of clinical trial. Methods The level of matrix metalloproteinase (MMP)‐1, tissue inhibitor of metalloproteinases (TIMPs), and pro‐inflammatory cytokines were measured in HaCaT cells following UVB irradiation. To evaluate the clinical safety of an agent containing 0.25% of TA‐III for use on human skin. Female subjects (n = 21) between the ages of 43 and 55 who met the criteria for subject selection were selected. They were beginning to form or had already formed wrinkles. Results UVB irradiation increased MMP‐1 expression and pro‐inflammatory cytokines. These increases were attenuated by TA‐III pretreatment of UVB‐exposed HaCaT cells. We found that the agent containing 0.25% of TA‐III ameliorated skin wrinkling. A comparison between groups showed that wrinkle parameters were significantly reduced after 12 weeks of product use (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|