Effects of immuno-related gene polymorphisms on a bispecific antibody targeting colorectal cancer cell
| Autor: | Cong-Min Zhang, Lin-Yu Yu, Liang Gong, Lan Fan, Xiao-Ping Chen, Hong-Hao Zhou, Jin-Feng Lv |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
CD3 Complex Genotype Pharmacogenomic Variants Colorectal cancer Cell Survival medicine.medical_treatment CD3 Cell 03 medical and health sciences 0302 clinical medicine Cell Line Tumor Antibodies Bispecific medicine Humans Precision Medicine Cytotoxicity Cell Proliferation Pharmacology biology business.industry Cancer Heterozygote advantage General Medicine Immunotherapy medicine.disease Epithelial Cell Adhesion Molecule HCT116 Cells digestive system diseases Healthy Volunteers 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Cancer research biology.protein Molecular Medicine business Colorectal Neoplasms |
| Zdroj: | Personalized medicine. 15(3) |
| ISSN: | 1744-828X |
| Popis: | Background: Colorectal cancer (CRC) represents the third most common type of cancer and the third leading cause of death from cancer around the world. M701 is a CD3/EpCAM bispecific antibody that shows promising cytotoxicity toward CRC cells. Aim: To investigate the influence of immuno-related gene polymorphisms on M701 mediated cytotoxicity to CRC cell HCT116. Method: We analyzed the influence of the effect of M701 on the activation and cytotoxicity of peripheral mononuclear blood cells from 129 healthy volunteers with different genotypes. Result: When incubated with M701, peripheral mononuclear blood cells from CD247 rs2949655 AA homozygotes showed significantly lower cytotoxicity than those from AG/GG heterozygotes. Conclusion: CD247 rs2949655 was significantly associated with the cytotoxicity of M701 to HCT116, which might contribute to personalized medicine of M701. |
| Databáze: | OpenAIRE |
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