Detection of Mycoplasma pneumoniae and Chlamydia pneumoniae in ruptured atherosclerotic plaques
| Autor: | Suely Aparecida Pinheiro Palomino, Maria de Lourdes Higuchi, José Antonio Franchini Ramires, Vera Demarchi Aiello, Lea Maria Macruz Demarchi, Paulo Sampaio Gutierrez, Nadia Vieira Sambiase |
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| Rok vydání: | 2000 |
| Předmět: |
Microscopy
Electron Scanning Transmission Mycoplasma pneumoniae Physiology Immunology Myocardial Infarction Biophysics Virulence Inflammation Coronary Artery Disease In situ hybridization Biology medicine.disease_cause Biochemistry Microbiology chemistry.chemical_compound Chlamydia pneumoniae Pneumonia Mycoplasma medicine Humans Myocardial infarction General Pharmacology Toxicology and Pharmaceutics lcsh:QH301-705.5 Rupture lcsh:R5-920 Chlamydia Cholesterol General Neuroscience Cell Biology General Medicine Chlamydia Infections Chlamydophila pneumoniae medicine.disease Vulnerable plaque lcsh:Biology (General) chemistry inflammation lipids (amino acids peptides and proteins) vulnerable plaque atherosclerosis medicine.symptom lcsh:Medicine (General) |
| Zdroj: | Scopus-Elsevier Brazilian Journal of Medical and Biological Research, Volume: 33, Issue: 9, Pages: 1023-1026, Published: SEP 2000 Brazilian Journal of Medical and Biological Research, Vol 33, Iss 9, Pp 1023-1026 (2000) |
| ISSN: | 0100-879X |
| Popis: | This paper reports what is apparently the first observation of Mycoplasma pneumoniae in association with Chlamydia pneumoniae in thrombosed ruptured atheromas. We performed electron microscopy and in situ hybridization in specimens from three patients who died of acute myocardial infarction. These patients had typical symptoms of acute ischemic syndrome. Mycoplasmas were present mainly in the lipid core of the ruptured thrombosed plaque. Vulnerable atheromas are rich in cholesterol and may favor the growth of mycoplasmas, the only microorganisms that require cholesterol for survival. We suggest that the association of Mycoplasma pneumoniae and Chlamydia pneumoniae may increase the virulence of these microorganisms, favoring proliferation, plaque inflammation and possibly plaque rupture. |
| Databáze: | OpenAIRE |
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