ELF regimen in advanced gastrointestinal malignancies: An analysis of its clinical effectiveness and toxicity
| Autor: | Carmelo Sciumè, G Cannata, A Cusumano, F. Verderame, Gebbia, S Fortunato, G Digesu, G. Curto, Roberto Valenza, Calogero Cipolla, Nicolo' Gebbia, Antonio Testa, P Leo |
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| Přispěvatelé: | Gebbia, V., Sciume, C., Cannata, G., Curto, G., Valenza, R., Testa, A., Cipolla, C., Cusumano, A., Verderame, F., Fortunato, S., Di Gesu, G., Leo, P., Gebbia, N. |
| Předmět: |
Oncology
medicine.medical_specialty Cancer Research Colorectal cancer Gastroenterology ELF Regimen Gall-bladder cancer Pancreatic cancer Internal medicine medicine ELF regimen Etoposide Leukopenia Performance status business.industry Stomach Folinic acid medicine.disease medicine.anatomical_structure Vomiting Fluorouracil medicine.symptom business Liver cancer Gastric cancer |
| Zdroj: | Scopus-Elsevier |
| Popis: | A multi-institutional phase 11 study of the combination of levofolinic acid 100 mg/m2, VP16 120 mg/m2 and 5-fluorouracil 500 mg/m2 for 3 consecutive days was carried out on a series of 73 evaluable patients with low performance status affected by locally advanced and/or metastatic gastrointestinal carcinomas. Site of primary tumor were: stomach 26, large bowel 20, pancreas 16, gall-bladder 5, and liver 6. Among patients with gastric carcinoma, 2 patients (8%) had a complete response with a mean duration of 6.8+ months, and 9 (35%) had a partial response with a mean duration of 5.8+ months, for an overall response rate of 43%. Overall response rate was largely unsatisfactory in colorectal carcinoma (20%), pancreatic (12%), gall-bladder and liver carcinomas. The treatment was very well tolerated with no grade 4 toxicity over a total of 267 cycles administered. Grade 3 leukopenia was seen in 25% of cases, and grade 2 thrombocytopenia in 18%. Vomiting never exceeded grade 2. Thus, the ELF regimen is quite active in advanced gastric carcinoma, and may be recommended as palliative treatment of patients who cannot receive intensive chemotherapy. On the other hand, it cannot be considered active in colorectal, pancreatic, gall-bladder and liver carcinomas, and its use should be discouraged in these neoplasms. |
| Databáze: | OpenAIRE |
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