The effects of methylene blue on renal scarring due to pyelonephritis in rats
| Autor: | Mustafa Inan, Şaban Gürcan, Hafize Uzun, Seval Aydin, Mehmet Pul, Burhan Aksu, Mehmet Kanter, Fulya Oz Puyan, Suleyman Ayvaz, Gulay Durmus-Altun |
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| Rok vydání: | 2007 |
| Předmět: |
inorganic chemicals
Nephrology medicine.medical_specialty medicine.drug_class Antibiotics Anti-Infective Agents Urinary Pharmacology Kidney medicine.disease_cause Drug Administration Schedule Rats Sprague-Dawley Cicatrix chemistry.chemical_compound Anti-Infective Agents Ciprofloxacin Internal medicine medicine Animals heterocyclic compounds Escherichia coli Escherichia coli Infections Escherichia coli K12 Pyelonephritis Inoculation business.industry Antimicrobial Renal scarring Rats Surgery Methylene Blue Disease Models Animal chemistry Pediatrics Perinatology and Child Health Drug Therapy Combination Female business Injections Intraperitoneal Methylene blue medicine.drug |
| Zdroj: | Pediatric Nephrology. 22:992-1001 |
| ISSN: | 1432-198X 0931-041X |
| Popis: | The aim of this study was to evaluate the efficiency of methylene blue (MB) in preventing renal scar formation after the induction of pyelonephritis (PNP) in a rat model with delayed antimicrobial therapy. An inoculum of the K-12 strain of Escherichia coli was injected into both kidneys. Control groups received isotonic saline instead of bacterial solution. Four equal groups were then formed: the PNP group was untreated and the PNP ciprofloxacin (CIP) treated group was treated only with CIP intraperitoneally (i.p.) starting on the third day following bacterial inoculation. In the PNP (MB)-treated group, MB was given i.p., and in the PNP MB + CIP-treated group, MB + CIP were administered i.p.. In the sixth week following bacterial inoculation, all rats were sacrificed, and both kidneys of the rats in all groups were examined biochemically and histopathologically for renal scarring. Renal scar was significant in the groups treated with MB alone or MB + CIP combination compared with untreated or antibiotic only groups. Delayed treatment with antibiotics had no effect on scarring. These results suggest that the addition of MB to the delayed antibiotic therapy might be beneficial in preventing PNP-induced oxidative renal tissue damage. |
| Databáze: | OpenAIRE |
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