Nocebo-Prone Behavior Associated with SARS-CoV-2 Vaccine Hesitancy in Healthcare Workers
| Autor: | Evrydiki Kravvariti, Konstantina Aravantinou-Fatorou, Maria Mylona, Eleni Korompoki, Meletios A. Dimopoulos, Georgia Papagiannopoulou, Pinelopi Vryttia, Georgios Tsivgoulis, Dimos D. Mitsikostas, Martina Amanzio, Petros P. Sfikakis, Athanasios Dellis, Eumorphia-Maria Delicha, Christina I. Deligianni |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
SARS‐CoV‐2
nocebo vaccine hesitancy healthcare workers tolerability adverse event Nocebo Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Immunology Article Drug Discovery Health care Medicine Pharmacology (medical) Adverse effect Pharmacology business.industry SARS-CoV-2 virus diseases Odds ratio Nocebo Effect Vaccination Infectious Diseases Tolerability business Demography |
| Zdroj: | Vaccines Volume 9 Issue 10 Vaccines, Vol 9, Iss 1179, p 1179 (2021) |
| ISSN: | 2076-393X |
| DOI: | 10.3390/vaccines9101179 |
| Popis: | Among healthcare workers (HCWs), SARS-CoV-2 vaccine hesitancy may be linked to a higher susceptibility to nocebo effects, i.e., adverse events (AEs) experienced after medical treatments due to negative expectations. To investigate this hypothesis a cross-sectional survey was performed with a self-completed questionnaire that included a tool (Q-No) for the identification of nocebo-prone individuals. A total of 1309 HCWs (67.2%women 43.4% physicians 28.4% nurses 11·5% administrative staff 16·6% other personnel) completed the questionnaires, among whom 237 (18.1%) had declined vaccination. Q-No scores were ≥15 in 325 participants (24.8%) suggesting nocebo-prone behavior. In a multivariate logistic regression model with Q-No score, age, gender, and occupation as independent variables, estimated odds ratios (ORs) of vaccination were 0.43 (i.e., less likely, p < 0.001) in participants with Q-No score ≥15 vs. Q-No score < 15, 0.58 in females vs. males (p = 0.013), and 4.7 (i.e., more likely) in physicians vs. other HCWs (p < 0.001), independent of age, which was not significantly associated with OR of vaccination. At least one adverse effect (AE) was reported by 67.5% of vaccinees, mostly local pain and flu-like symptoms. In a multivariate logistic regression model, with Q-No score, age, gender, and occupation as independent variables, estimated ORs of AE reporting were 2.0 in females vs. males (p < 0.001) and 1.47 in physicians vs. other HCWs (p = 0.017) independently of age and Q-No score, which were not significantly associated with OR of AE. These findings suggest that nocebo-prone behavior in HCWs is associated with SARS-CoV-2 vaccination hesitancy indicating a potential benefit of a campaign focused on nocebo-prone people. |
| Databáze: | OpenAIRE |
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