The dynamics of chromosome evolution in birds and mammals
| Autor: | Alexei A Sazanov, David W. Burt, Jacqueline Smith, Charlotte Bruley, Anne Ramage, Ruedi Fries, Ian C. Dunn, Cheryl Jones, Andy Law, David R. Morrice, Ian R. Paton, D. Waddington, D Windsor |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Biology
Models Biological Genome Chromosomes Birds Evolution Molecular Mice Gene mapping Molecular evolution Animals Chromosomes Human Humans Gene Synteny Genomic organization Gene Rearrangement Mammals Genetics Multidisciplinary Genome Human Chromosome Mapping Chromosome Evolutionary biology Mutation Human genome Chickens |
| Zdroj: | Nature. 402:411-413 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/46555 |
| Popis: | Comparative mapping, which compares the location of homologous genes in different species, is a powerful tool for studying genome evolution1. Comparative maps suggest that rates of chromosomal change in mammals can vary from one to ten rearrangements per million years1,2,3,4. On the basis of these rates we would expect 84 to 600 conserved segments in a chicken comparison with human or mouse. Here we build comparative maps between these species and estimate that numbers of conserved segments are in the lower part of this range. We conclude that the organization of the human genome is closer to that of the chicken than the mouse and by adding comparative mapping results from a range of vertebrates, we identify three possible phases of chromosome evolution. The relative stability of genomes such as those of the chicken and human will enable the reconstruction of maps of ancestral vertebrates. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|