Early oral cavity cancer: The prognostic factors and impact of adjuvant radiation on survival
| Autor: | Ghanashyam Mandal, Udip Maheshwari, Rajeev Kumar, Sumit Goyal, Dharma Ram, Venkata Pradeep Babu Koyyala, Ajay K. Dewan, Suhas Kodasoge Rajappa |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Oncology Subset Analysis medicine.medical_specialty Databases Factual medicine.medical_treatment Oral Surgical Procedures Oral cavity Risk Assessment Disease-Free Survival Cohort Studies 03 medical and health sciences 0302 clinical medicine Cause of Death Internal medicine medicine Adjuvant therapy Humans Neoplasm Invasiveness In patient Early Detection of Cancer Neoplasm Staging Retrospective Studies Mouth Adjuvant radiotherapy business.industry Cancer 030206 dentistry Prognosis medicine.disease Survival Analysis humanities Otorhinolaryngology Depth of invasion 030220 oncology & carcinogenesis Carcinoma Squamous Cell Female Mouth Neoplasms Radiotherapy Adjuvant business Adjuvant |
| Zdroj: | Head & Neck. 41:3577-3583 |
| ISSN: | 1097-0347 1043-3074 |
| Popis: | Background Early oral cavity cancer has good prognosis but recurrence in them is still not uncommon. There is no general consensus on the prognostic factors and adjuvant therapy that would have a significant impact on survival. Methods A retrospective analysis of early oral cavity cancer patients during the time period 2009-2017. The data regarding demographics, histopathological features, and recurrence patterns were collected and analyzed. Results Depth of invasion (DOI) was the most important prognostic factor among all the factors analyzed. Further analysis showed that addition of adjuvant radiotherapy for patients with DOI >5 mm did not show survival benefits (P = .73). Another subset analysis of patients with DOI >10 mm also did not show any survival advantage with adjuvant therapy P = .24. Conclusion There is no benefit of adding adjuvant RT in patients with DOI > 5 mm or in patients who were upstaged to T3 based only on DOI. |
| Databáze: | OpenAIRE |
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