Cancer-associated fibroblast senescence and its relation with tumour-infiltrating lymphocytes and PD-L1 expressions in intrahepatic cholangiocarcinoma
| Autor: | Yasuharu Ikeda, Yuki Kitano, Takanobu Yamao, Tomoharu Yoshizumi, Chuan Lan, Hideo Baba, Yo-ichi Yamashita, Keishi Sugimachi, Kiyoshi Kajiyama, Nobutomo Miyanari, Masahiko Hirota, Hiroshi Takamori, Kengo Fukuzawa |
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| Rok vydání: | 2021 |
| Předmět: |
Senescence
Male Cancer Research Lymphocyte Caveolin 1 chemical and pharmacologic phenomena CD8-Positive T-Lymphocytes Article B7-H1 Antigen Cholangiocarcinoma Lymphocytes Tumor-Infiltrating Cancer-Associated Fibroblasts PD-L1 Carcinoma Medicine Humans Intrahepatic Cholangiocarcinoma Cellular Senescence Aged biology business.industry FOXP3 Correction hemic and immune systems Forkhead Transcription Factors medicine.disease Prognosis Survival Rate medicine.anatomical_structure Oncology Bile Duct Neoplasms Cancer cell Cancer research biology.protein Immunohistochemistry Female business |
| Zdroj: | Br J Cancer |
| ISSN: | 1532-1827 |
| Popis: | BACKGROUND: Caveolin-1 (CAV1) in cancer-associated fibroblasts (CAFs) has pro- or anti-tumourigenic effect depending on the cancer type. However, its effect in intrahepatic carcinoma (ICC) remains unknown. Therefore, this study aimed to investigate the relationship between CAV1 in CAFs and tumour-infiltrating lymphocyte (TIL) numbers or PD-L1 levels in ICC patients. METHODS: Consecutive ICC patients (n = 158) were enrolled in this study. The levels of CAV1 in CAFs, CD8 + TILs, Foxp3+ TILs and PD-L1 in cancer cells were analysed using immunohistochemistry. Their association with the clinicopathological factors and prognosis were evaluated. The correlation between these factors was evaluated. RESULTS: CAV1 upregulation in CAFs was associated with a poor overall survival (OS) (P |
| Databáze: | OpenAIRE |
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