Genome-scale portrait and evolutionary significance of human-specific core promoter tri- and tetranucleotide short tandem repeats

Autor: T. Abbasi-Asl, N. Nazaripanah, Fatemeh Adelirad, Mina Ohadi, Ahmad Delbari, R. Sahaf
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: Human Genomics, Vol 12, Iss 1, Pp 1-8 (2018)
Human Genomics
ISSN: 1479-7364
DOI: 10.1186/s40246-018-0149-3
Popis: Background While there is an ongoing trend to identify single nucleotide substitutions (SNSs) that are linked to inter/intra-species differences and disease phenotypes, short tandem repeats (STRs)/microsatellites may be of equal (if not more) importance in the above processes. Genes that contain STRs in their promoters have higher expression divergence compared to genes with fixed or no STRs in the gene promoters. In line with the above, recent reports indicate a role of repetitive sequences in the rise of young transcription start sites (TSSs) in human evolution. Results Following a comparative genomics study of all human protein-coding genes annotated in the GeneCards database, here we provide a genome-scale portrait of human-specific short- and medium-size (≥ 3-repeats) tri- and tetranucleotide STRs and STR motifs in the critical core promoter region between − 120 and + 1 to the TSS and evidence of skewing of this compartment in reference to the STRs that are not human-specific (Levene’s test p
Databáze: OpenAIRE
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