Radio-Fluorogenic Gel Dosimetry with Coumarin
| Autor: | Michael Lamba, Howard R. Elson, Henry Fenichel, Brandt P. Bastow, Peter Sandwall, William B. Connick, Henry B. Spitz |
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| Rok vydání: | 2018 |
| Předmět: |
Radical
Bioengineering 02 engineering and technology Gel dosimetry lcsh:Technology Article 030218 nuclear medicine & medical imaging Ionizing radiation 03 medical and health sciences 0302 clinical medicine Dosimetry lcsh:QH301-705.5 Aqueous solution Dosimeter lcsh:T Chemistry Radiochemistry 021001 nanoscience & nanotechnology Fluorescence radiation dosimetry lcsh:Biology (General) Radiolysis radio-fluorogenic gel luminescent dosimetry gel dosimetry 0210 nano-technology |
| Zdroj: | Bioengineering Bioengineering, Vol 5, Iss 3, p 53 (2018) Volume 5 Issue 3 |
| ISSN: | 2306-5354 |
| Popis: | Gel dosimeters are attractive detectors for radiation therapy, with properties similar to biological tissue and the potential to visualize volumetric dose distributions. Radio-fluorogenesis is the yield of fluorescent chemical products in response to energy deposition from ionizing radiation. This report shares the development of a novel radio-fluorogenic gel (RFG) dosimeter, gelatin infused with coumarin-3-carboxlyic acid (C3CA), for the quantification of imparted energy. Aqueous solutions exposed to ionizing radiation result in the production of hydroxyl free radicals through water radiolysis. Interactions between hydroxyl free radicals and coumarin-3-carboxylic acid produce a fluorescent product. 7-hydroxy-coumarin-3-carboxylic acid has a blue (445 nm) emission following ultra-violet (UV) to near UV (365&ndash 405 nm) excitation. Effects of C3CA concentration and pH buffers were investigated. The response of the RFG was explored with respect to strength, type, and exposure rate of high-energy radiation. Results show a linear dose response relationship independent of energy and type, with a dose-rate dependency. This report demonstrates increased photo-yield with high pH and the utility of gelatin-RFG for phantom studies of radiation dosimetry. |
| Databáze: | OpenAIRE |
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