| Autor: |
Cifani, Noemi, Proietta, Maria, Dezi, Tommaso, Luciani, Michelangelo, Raffa, Salvatore, Rizzo, Luigi, Ranieri, Danilo, Taurino, Maurizio, DEL PORTO, Flavia |
| Rok vydání: |
2020 |
| Předmět: |
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| Zdroj: |
Angiology & Vascular Surgery. 5:1-6 |
| ISSN: |
2572-7397 |
| DOI: |
10.24966/avs-7397/100047 |
| Popis: |
Background: The aim of this study was to evaluate miRNA-33 and miRNA-155 expression in Peripheral Blood Mononuclear Cells (PBMC) and carotid specimens of patients affected by Critical Carotid Artery Stenosis (CAS). Material and Methods: We selected 17 asymptomatic (CAS-A group) and 10 symptomatic (CAS-S group) patients with CAS. Ten patients with traditional cardiovascular risk factors (RF group), matched for age and sex, were used as control group. Results: A significant increase in miRNA-33 expression was observed both in peripheral blood and in carotid specimens of CAS-A patients (p 0.04) in comparison with CAS-S and RF, whereas no significant difference were found among the groups regarding miRNA-155 expression both in peripheral blood and in carotid specimens. Conclusions: This is to our knowledge the first report on miRNAs expression in human PBMCs from CAS patients. Results of this study suggest that miRNA-33 in involved in the process underling plaque formation and growth, but not in plaque instability and ischemic brain damage, whereas miRNA-155 is expressed during all the phases of atherosclerotic disease. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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