Impaired Prenatal Development and Glycemic Status in the Offspring of Rats with Experimental Streptozotocin-Induced Diabetes and Their Correction with Afobazole
| Autor: | Andrey D. Durnev, V. V. Zabrodina, O. V. Shreder, S. B. Seredenin, E. D. Shreder |
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| Rok vydání: | 2014 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Offspring Morpholines medicine.medical_treatment Intraperitoneal injection Pregnancy in Diabetics Embryonic Development Streptozocin General Biochemistry Genetics and Molecular Biology Diabetes Mellitus Experimental Pregnancy Internal medicine Edema Diabetes mellitus Animals Outbred Strains medicine Animals business.industry General Medicine medicine.disease Streptozotocin Prenatal development Rats Endocrinology Prenatal Exposure Delayed Effects Gestation Benzimidazoles Female medicine.symptom business medicine.drug |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 158:16-20 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-014-2681-z |
| Popis: | Diabetes mellitus was simulated in rats on gestation day 1 by a single intraperitoneal injection of streptozotocin in doses of 40 and 50 mg/kg. Pregnant females showed increased glucose concentrations n the blood and urine, embryonic developmental disorders, such as tongue protrusion, edema, and skin hyperemia with concomitant vascular damage (hemorrhage, hematoma) as well as pre- and post-implantation embryo loss. Afobazole administered orally in doses of 10 and 50 mg/kg to pregnant rats with streptozotocin-induced diabetes significantly decreased prenatal developmental disorders and pre- and post-implantation embryo loss rate. Afobazole in a dose of 50 mg/kg produced maximum protective effect: in rats receiving 40 mg/kg streptozotocin, post-implantation embryo loss decreased by 14.7 times. Afobazole in doses of 10 and 50 mg/kg significantly reduced blood glucose concentration in pregnant rats and normalized glycemia in 90-day-old male offspring. |
| Databáze: | OpenAIRE |
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