The efficacy of evolocumab in the management of hyperlipidemia: a systematic review
| Autor: | Lamia AlHajri, Shama AlMheiri, Zainab AlHashimi, Yalwah AlMutawa, Asma AlHadhrami |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Serine Proteinase Inhibitors Hypercholesterolemia Review 030204 cardiovascular system & hematology Antibodies Monoclonal Humanized 03 medical and health sciences 0302 clinical medicine Internal medicine Hyperlipidemia medicine Humans Pharmacology (medical) 030212 general & internal medicine medicine.diagnostic_test business.industry Anticholesteremic Agents PCSK9 Inhibitors Antibodies Monoclonal Cholesterol LDL medicine.disease Evolocumab Treatment Outcome Proprotein Convertase 9 Cardiology and Cardiovascular Medicine Lipid profile business Biomarkers Dyslipidemia |
| Zdroj: | Therapeutic Advances in Cardiovascular Disease. 11:155-169 |
| ISSN: | 1753-9455 1753-9447 |
| Popis: | Background: Hyperlipidemia or dyslipidemia has been a concern for a long time, with various guidelines emphasizing the importance of managing the lipid profile to prevent cardiac incidences. Although statins have been found to be highly effective, resistance and intolerability to side effects will continue to be a stumbling block for certain patients. Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors tackle lipid profile via a novel mechanism and therefore provide an additional effective option for managing lipid profile. The overarching aim of this systematic review was to evaluate the efficacy of evolocumab among various populations with hypercholesterolemia. Methods: A comprehensive search was conducted in ProQuest Health & Medical Complete, Google Scholar, ScienceDirect, and PubMed to identify potential records; then titles, abstracts, and full texts were screened using the inclusion criteria to filter out irrelevant studies. Data extraction and quality assessment were undertaken using standardized tools and the results were narratively synthesized and presented in tables. Results: Eight studies were included in this systematic review after screening 1191 records. All studies demonstrated a statistically significant reduction in low-density lipoprotein cholesterol (LDL-C) values in the groups that received evolocumab compared with the comparator groups ( p < 0.05). The decline in LDL-C levels from baseline in the majority of studies ranged from 40% to 80%, whether used alone or in combination with other agents. Also, high-density lipoprotein cholesterol, lipoprotein (a) and apolipoprotein B were improved with the use of evolocumab. Conclusions: This study helped to collate evidence from studies that tested the effectiveness of evolocumab in the management of hyperlipidemia. Evolocumab seems to be highly effective in reducing LDL-C and other lipid parameters. Hence, it provides an excellent alternative for patients with refractory disease or patients who develop intolerable side effects, therefore helping to overcome the stumbling block to achieving optimal lipid management. |
| Databáze: | OpenAIRE |
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