Serum electrolyte and blood gas changes after intrathecal and intravenous bolus injections of magnesium sulphate An experimental study in a rat model
| Autor: | M. L. Cohen, Y. Grinshpun, H. Nissenbaum, R. Datski, J. L. Zaidman, J. Kaufman, M. Bahar, M. Chanimov |
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| Rok vydání: | 1997 |
| Předmět: |
Male
medicine.medical_specialty Partial Pressure Sodium Potassium chemistry.chemical_element Electrolyte Calcium Anesthesia Spinal Electrolytes Magnesium Sulfate Route of administration Internal medicine medicine Animals Magnesium Rats Wistar Injections Spinal Anesthetics business.industry Carbon Dioxide Rats Oxygen Anesthesiology and Pain Medicine Endocrinology chemistry Injections Intravenous Arterial blood business Homeostasis |
| Zdroj: | Anaesthesia. 52:1065-1069 |
| ISSN: | 1365-2044 0003-2409 |
| DOI: | 10.1111/j.1365-2044.1997.218-az0352.x |
| Popis: | The effect of intrathecally administered magnesium sulphate on serum levels of magnesium, sodium, potassium, calcium and blood gas variables was studied in a rat model. Magnesium sulphate given intrathecally has previously been shown to produce segmental spinal blockade with no permanent neurological damage. The previous studies, however, had not investigated the possible systemic effects of the magnesium sulphate. The serum magnesium level increased significantly at 1 and 2 h after the intrathecal injection of both 6.3% and 12.6% magnesium sulphate (6.3%: 28% at 1 h, 24% at 2 h; 12.6%: 22% at 1 h, 16% at 2 h). These changes were not as great as occurred when the same dose of magnesium sulphate was administered intravenously. In all cases, the serum magnesium had returned to normal by 24 h. There were no significant changes in calcium, sodium or potassium levels, nor in arterial blood gas variables. These results show that intrathecally administered magnesium sulphate has little effect on electrolyte homeostasis. |
| Databáze: | OpenAIRE |
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