The post-prandial state in Type 2 diabetes and endothelial dysfunction: effects of insulin aspart
| Autor: | Antonio Ceriello, Lisa Quagliaro, G. Marra, Lucia Martinelli, R. Da Ros, Enrico Motz, Alessandro Cavarape, Roberta Assaloni, Ludovica Piconi |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty endocrine system diseases Endothelium Endocrinology Diabetes and Metabolism Type 2 diabetes Insulin aspart chemistry.chemical_compound Endocrinology Diabetes mellitus Internal medicine Internal Medicine medicine Humans Hypoglycemic Agents Insulin Endothelial dysfunction Triglycerides Triglyceride business.industry Fatty Acids digestive oral and skin physiology Area under the curve Middle Aged Postprandial Period medicine.disease medicine.anatomical_structure Diabetes Mellitus Type 2 chemistry Hyperglycemia Regular insulin Female Endothelium Vascular business Diabetic Angiopathies medicine.drug |
| Zdroj: | Diabetic Medicine. 21:171-175 |
| ISSN: | 1464-5491 0742-3071 |
| Popis: | Objective Recently, much attention has been focused on the possibility that the post-prandial state may be a cardiovascular risk factor in diabetes. The aim of the present study was to evaluate whether the post-prandial state is associated with endothelial dysfunction in patients with diabetes and to explore the effect on this aspect of managing post-prandial hyperglycaemia by insulin aspart. Research design and methods Twenty-three patients with Type 2 diabetes and 10 normal controls were recruited. In the diabetic patients two different tests were performed in each subject: a standard meal preceded by subcutaneous injection of soluble insulin (0.15 U/kg body weight) or of short-acting insulin aspart (0.15 U/kg body weight). These tests were designed to achieve different levels of post-prandial hyperglycaemia. Controls received a single standard meal test. Immediately before, and 1, 2, 4 and 6 h after each meal, blood glucose, triglycerides, free fatty acids and flow-mediated vasodilation were measured. Results Compared with regular insulin, insulin aspart significantly reduced the area under the curve for post-prandial hyperglycaemia (58.3 ± 17.6 vs. 68.1 ± 17.7; P |
| Databáze: | OpenAIRE |
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