Sucralfate and ranitidine twice daily in the treatment of gastric ulcer. A multicenter randomized double-blind study
| Autor: | E. Mallas, G. Kitis, Athanasios J. Archimandritis, M. Tjivras, N. Charitopoulos, G. Kokozidis, T. Diamantis |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male medicine.medical_specialty Evening medicine.medical_treatment Sucralfate Ranitidine Gastroenterology Drug Administration Schedule law.invention Histamine H2 receptor Randomized controlled trial Double-Blind Method law Internal medicine medicine Humans Stomach Ulcer Morning Aged Chemotherapy business.industry Stomach Middle Aged medicine.anatomical_structure Female business medicine.drug Follow-Up Studies |
| Zdroj: | Journal of clinical gastroenterology. 14(1) |
| ISSN: | 0192-0790 |
| Popis: | Sucralfate and ranitidine were compared in the treatment of gastric ulcer (GU) in this multicenter randomized double-blind study. Sixty-four patients with endoscopically diagnosed GU initially included in the trial were randomly assigned to treatment with sucralfate, 2 g b.i.d. (morning and evening on an empty stomach), or ranitidine, 150 mg b.i.d. Nine patients were subsequently excluded for various reasons. The remaining 55 were examined endoscopically after 4 and, if unhealed, 8 weeks. At 4 weeks, 54.2% (13 of 24) of the sucralfate group had a healed ulcer, in comparison to 45.2% (14 of 31) of the ranitidine group (NS). At 8 weeks, cumulative healing rates were 87.5% (21 of 24) and 84% (26 of 31), respectively (NS). No differences were found in the healing effects of the drugs on smokers and nonsmokers or in side effects. These results suggest that both drugs are equally effective in the short-term treatment of GU. |
| Databáze: | OpenAIRE |
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