Estrogen Receptor on the move: Cistromic plasticity and its implications in breast cancer

Autor: Wilbert Zwart, Isabel Mayayo-Peralta, Stefan Prekovic
Přispěvatelé: Chemical Biology
Rok vydání: 2021
Předmět:
0301 basic medicine
Cell signaling
Clinical Biochemistry
Estrogen receptor
Breast Neoplasms
Breast Neoplasms/genetics
Biology
SDG 3 – Goede gezondheid en welzijn
Biochemistry
Cell Line
03 medical and health sciences
Breast cancer
Transcriptional regulation
0302 clinical medicine
SDG 3 - Good Health and Well-being
Kinase signaling
Cell Line
Tumor
Receptors
medicine
Humans
Molecular Biology
Transcription factor
Neoplastic
Tumor
Chromatin binding
Estrogen Receptor alpha/genetics
Estrogen Receptor alpha
Cancer
General Medicine
medicine.disease
Estrogen
Gene Expression Regulation
Neoplastic
030104 developmental biology
Receptors
Estrogen
ESR1 mutants
Gene Expression Regulation
Cistrome
030220 oncology & carcinogenesis
Cancer research
Molecular Medicine
Steroid hormone receptor crosstalk
Female
Cistromic plasticity
Zdroj: Molecular Aspects of Medicine, 78:100939. Elsevier
ISSN: 0098-2997
Popis: Estrogen Receptor (ERα) is a hormone-driven transcription factor, critically involved in driving tumor cell proliferation in the vast majority of breast cancers (BCas). ERα binds the genome at cis-regulatory elements, dictating the expression of a large spectrum of responsive genes in 3D genomic space. While initial reports described a rather static ERα chromatin binding repertoire, we now know that ERα DNA interactions are highly versatile, altered in breast tumor development and progression, and deviate between tumors from patients with differential outcome. Multiple cellular signaling cascades are known to impinge on ERα genomic function, changing its cistrome to retarget the receptor to other regions of the genome and reprogram its impact on breast cell biology. This review describes the current state-of-the-art on which factors manipulate the ERα cistrome and how this alters the response to both endogenous and exogenous hormonal stimuli, ultimately impacting BCa cell progression and response to commonly used therapeutic interventions. Novel insights in ERα cistrome dynamics may pave the way for better patient diagnostics and the development of novel therapeutic interventions, ultimately improving cancer care and patient outcome.
Databáze: OpenAIRE
Externí odkaz: