Dietary supplementation with whey protein improves systemic microvascular function in heart failure patients: a pilot study

Autor: Lorenzo, A. De, Santos, E.M. Dos, Bello Moreira, A.S., Huguenin, G.V.B., Tibirica, E.
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
0301 basic medicine
Medicine (General)
Physiology
Vasodilator Agents
Pilot Projects
Vasodilation
Biochemistry
Gastroenterology
0302 clinical medicine
Biology (General)
General Pharmacology
Toxicology and Pharmaceutics
Endothelial dysfunction
Dietary supplementation
Skin
General Neuroscience
General Medicine
Middle Aged
Pathophysiology
Microvascular reactivity
medicine.anatomical_structure
030220 oncology & carcinogenesis
Sodium nitroprusside
Research Article
medicine.drug
medicine.medical_specialty
Endothelium
QH301-705.5
Immunology
Biophysics
Ocean Engineering
Placebo
Microcirculation
03 medical and health sciences
R5-920
Internal medicine
medicine
Humans
Laser speckle contrast imaging
Aged
Heart Failure
business.industry
Endothelial function
Cell Biology
medicine.disease
Whey Proteins
030104 developmental biology
Heart failure
Dietary Supplements
Skin iontophoresis
Endothelium
Vascular
business
Zdroj: Brazilian Journal of Medical and Biological Research v.54 n.6 2021
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Brazilian Journal of Medical and Biological Research, Volume: 54, Issue: 6, Article number: e10577, Published: 19 APR 2021
Popis: Endothelial dysfunction is a well-known component of the pathophysiology of heart failure (HF), with proven prognostic value. Dietary supplementation with whey protein (WP) has been widely used to increase skeletal muscle mass, but it also has vascular effects, which are less understood. This study aimed to evaluate the effects of WP supplementation on the systemic microvascular function of HF patients. This was a blinded, randomized, placebo-controlled clinical trial that evaluated the effects of 12-week WP dietary supplementation on systemic microvascular function, in patients with HF New York Heart Association (NYHA) classes I/II. Cutaneous microvascular flow and reactivity were assessed using laser speckle contrast imaging, coupled with pharmacological local vasodilator stimuli. Fifteen patients (aged 64.5±6.2 years, 11 males) received WP supplementation and ten patients (aged 68.2±8.8 years, 8 males) received placebo (maltodextrin). The increase in endothelial-dependent microvascular vasodilation, induced by skin iontophoresis of acetylcholine, was improved after WP (P=0.03) but not placebo (P=0.37) supplementation. Moreover, endothelial-independent microvascular vasodilation induced by skin iontophoresis of sodium nitroprusside, was also enhanced after WP (P=0.04) but not placebo (P=0.42) supplementation. The results suggested that dietary supplementation with WP improved systemic microvascular function in patients with HF.
Databáze: OpenAIRE
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