| Autor: |
Nahomy Ledesma Vicioso, Diana Lin, Daniel R. Gomez, Jonathan T. Yang, Nancy Y. Lee, Andreas Rimner, Yoshiya Yamada, Michael J. Zelefsky, Noah S. Kalman, Charles E. Rutter, Rupesh R. Kotecha, Minesh P. Mehta, Joseph E. Panoff, Michael D. Chuong, Andrew L. Salner, Jamie S. Ostroff, Lisa C. Diamond, Noah J. Mathis, Oren Cahlon, David G. Pfister, Zhigang Zhang, Fumiko Chino, Jillian Tsai, Erin F. Gillespie |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
JCO Oncol Pract |
| Popis: |
PURPOSE: Community-academic partnerships have the potential to improve access to clinical trials for under-represented minority patients who more often receive cancer treatment in community settings. In 2017, the Memorial Sloan Kettering (MSK) Cancer Center began opening investigator-initiated clinical trials in radiation oncology in targeted community-based partner sites with a high potential to improve diverse population accrual. This study evaluates the effectiveness of a set of implementation strategies for increasing overall community-based enrollment and the resulting proportional enrollment of Hispanic patients on trials on the basis of availability in community-based partner sites. METHODS: An interrupted time series analysis evaluating implementation strategies was conducted from April 2018 to September 2021. Descriptive analysis ofHispanic enrollment on investigator-initiated randomized therapeutic radiation trials open at community-based sites was compared with those open only at themain academic center. RESULTS: Overall, 84 patients were enrolled in clinical trials in the MSK Alliance, of which 48 (56%) identified as Hispanic. The quarterly patient enrollment pre- vs postimplementation increased from 1.39 (95% CI, –3.67 to 6.46) to 9.42 (95% CI, 2.05 to 16.78; P5 .017). In the investigator-initiated randomized therapeutic radiation trials open in the MSK Alliance, Hispanic representation was 11.5% and 35.9% in twometastatic trials and 14.2% in a proton versus photon trial. Inmatched trials open only at the main academic center, Hispanic representation was 5.6%, 6.0%, and 4.0%, respectively. CONCLUSION: A combination of practice-level and physician-level strategies implemented at community-based partner sites was associated with increased clinical trial enrollment, which translated to improved Hispanic representation. This supports the role Q:2 of strategic community-academic partnerships in addressing disparities in clinical trial enrollment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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