Environmental exposures and child and maternal gut microbiota in rural Malawi
| Autor: | Yue-Mei Fan, Emma Kortekangas, Yin Bun Cheung, Arox W. Kamng’ona, Kathryn G. Dewey, Ulla Ashorn, Kenneth Maleta, Andrew Matchado, Basho Poelman, Per Ashorn |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Malawi Epidemiology Water source HIV Infections Gut flora digestive system Child Nutrition Disorders Child health Feces 03 medical and health sciences 0302 clinical medicine Childhood malnutrition Abundance (ecology) Environmental health Humans socio‐economic factors Medicine 030212 general & internal medicine Intervention trial Antibiotic use seasons 030219 obstetrics & reproductive medicine Bacteria gut microbiota biology Nutritional Support business.industry Infant Environmental Exposure biology.organism_classification Infant Nutrition Disorders Gastrointestinal Microbiome UniFrac Nutrition Assessment Socioeconomic Factors Child Preschool Pediatrics Perinatology and Child Health child health Educational Status Childhood Outcomes Female Original Article business environment |
| Zdroj: | Paediatric and Perinatal Epidemiology |
| ISSN: | 1365-3016 0269-5022 |
| DOI: | 10.1111/ppe.12623 |
| Popis: | Author(s): Kortekangas, Emma; Kamng'ona, Arox W; Fan, Yue-Mei; Cheung, Yin Bun; Ashorn, Ulla; Matchado, Andrew; Poelman, Basho; Maleta, Kenneth; Dewey, Kathryn G; Ashorn, Per | Abstract: BackgroundGut microbiota composition is associated with child health, but the effect of the environment on microbiota composition is not well understood. Few studies have been conducted in low-income settings where childhood malnutrition is common and possibly related to microbiota composition.ObjectivesTo investigate whether gut microbiota composition in young children and their mothers is associated with different environmental exposures in rural Malawi. We hypothesized that more adverse environmental exposures would be associated with lower levels of microbiota maturity and diversity.MethodsFaecal samples from up to 631 children and mothers participating in a nutrition intervention trial were collected at 1, 6, 12, 18, and 30nmonths (children) and at 1nmonth (mothers) after birth and analysed for microbiota composition with 16S rRNA sequencing. Bacterial OTU and genus abundances, measures of microbiota maturity and diversity, and UniFrac distances were compared between participants with different environmental exposures. The exposure variables included socio-economic status, water source, sanitary facility, domestic animals, maternal characteristics, season, antibiotic use, and delivery mode.ResultsMeasures of microbiota maturity and diversity in children were inversely associated with maternal education at 6, 18, and 30nmonths and did not otherwise differ consistently between participants with different environmental exposures. Phylogenetic distance was related to season of stool sample collection at all time points. At the level of individual OTUs and genera, season of stool sample collection, type of water source, and maternal education showed most associations with child gut microbiota, while HIV status was the most important predictor of relative OTU and genus abundances in mothers.ConclusionThe results do not support the hypothesis that adverse environmental exposures are broadly associated with lower microbiota maturity and diversity but suggest that environmental exposures influence the abundance of several bacterial OTUs and genera and that low maternal education is associated with higher microbiota maturity and diversity. |
| Databáze: | OpenAIRE |
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