Association of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 Infection

Autor: Marcus Miranda Lessa, Clara Mônica Figueiredo de Lima, Natália Carvalho, Isadora Cristina de Siqueira, Valéria Bittencourt, Adriana Dourado, Silvane Santos, Edgar M. Carvalho
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Adult
Male
0301 basic medicine
lcsh:Immunologic diseases. Allergy
Article Subject
Cross-sectional study
medicine.medical_treatment
030106 microbiology
Immunology
Proinflammatory cytokine
Pathogenesis
Interferon-gamma
03 medical and health sciences
Myelopathy
0302 clinical medicine
Proviruses
Antigen
stomatognathic system
Sicca syndrome
medicine
Humans
Immunology and Allergy
030203 arthritis & rheumatology
Human T-lymphotropic virus 1
Tumor Necrosis Factor-alpha
business.industry
General Medicine
Middle Aged
Viral Load
medicine.disease
Dry mouth
HTLV-I Infections
eye diseases
Interleukin-10
stomatognathic diseases
Cross-Sectional Studies
Sjogren's Syndrome
Cytokine
Gene Expression Regulation
Host-Pathogen Interactions
Female
Interleukin-5
medicine.symptom
business
lcsh:RC581-607
Signal Transduction
Research Article
Zdroj: Journal of Immunology Research, Vol 2016 (2016)
Journal of Immunology Research
ISSN: 2314-8861
DOI: 10.1155/2016/8402059
Popis: TheSjögrensyndrome has been diagnosed in patients with HTLV-1 associated myelopathy and dry mouth and dry eyes are documented in HTLV-1 carriers. However the diagnosis ofSjögrensyndrome in these subjects has been contested. In this cross-sectional study, we evaluated the role of immunological factors and proviral load, in sicca syndrome associated with HTLV-1 in patients without myelopathy. Subjects were recruited in the HTLV-1 Clinic, from 2009 to 2011. The proviral load and cytokine levels (IFN-γ, TNF-α, IL-5, and IL-10) were obtained from a database containing the values presented by the subjects at admission in the clinic. Of the 272 participants, 59 (21.7%) had sicca syndrome and in all of them anti-Sjögrensyndrome related antigen A (SSA) and antigen B (SSB) were negatives. The production of TNF-αand IFN-γwas higher in the group with sicca syndrome (P<0.05) than in HTLV-1 infected subjects without sicca syndrome. Our data indicates that patients with sicca syndrome associated with HTLV-1 do not haveSjögrensyndrome. However the increased production of TNF-αand IFN-γin this group of patients may contribute to the pathogenesis of sicca syndrome associated with HTLV-1.
Databáze: OpenAIRE
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