Collagens and proteoglycans of the cornea: importance in transparency and visual disorders

Autor: François Malecaze, Stéphane Galiacy, Dawiyat Massoudi
Přispěvatelé: Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées, Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse]
Rok vydání: 2015
Předmět:
0301 basic medicine
Corneal opacities
Histology
genetic structures
Vision Disorders
Models
Biological
FACIT
Pathology and Forensic Medicine
Cornea
MESH: Vision Disorders / metabolism
Extracellular matrix
03 medical and health sciences
Stroma
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
MESH: Collagen / metabolism
medicine
Animals
Humans
MESH: Animals
MESH: Cornea / physiopathology
Wound Healing
MESH: Humans
Chemistry
Corneal transparency
MESH: Models
Biological
Cell Biology
Anatomy
MESH: Cornea / pathology
eye diseases
Type V collagen
Epithelium
MESH: Cornea / metabolism
Cell biology
SLRPs
MESH: Wound Healing
Visual Disorders
030104 developmental biology
medicine.anatomical_structure
MESH: Vision Disorders / physiopathology
Proteoglycans
Collagen
sense organs
Collagens
MESH: Proteoglycans / metabolism
Zdroj: Cell and Tissue Research
Cell and Tissue Research, Springer Verlag, 2016, 363 (2), pp.337-349. ⟨10.1007/s00441-015-2233-5⟩
ISSN: 1432-0878
0302-766X
DOI: 10.1007/s00441-015-2233-5
Popis: International audience; The cornea represents the external part of the eye and consists of an epithelium, a stroma and an endothelium. Due to its curvature and transparency this structure makes up approximately 70% of the total refractive power of the eye. This function is partly made possible by the particular organization of the collagen extracellular matrix contained in the corneal stroma that allows a constant refractive power. The maintenance of such an organization involves other molecules such as type V collagen, FACITs (fibril-associated collagens with interrupted triple helices) and SLRPs (small leucine-rich proteoglycans). These components play crucial roles in the preservation of the correct organization and function of the cornea since their absence or modification leads to abnormalities such as corneal opacities. Thus, the aim of this review is to describe the different corneal collagens and proteoglycans by highlighting their importance in corneal transparency as well as their implication in corneal visual disorders.
Databáze: OpenAIRE
Externí odkaz: