MTHFR (C677T, A1298C), FV Leiden polymorphisms, and the prothrombin G20210A mutation in arterial ischemic stroke among young tunisian adults
| Autor: | Choumous Kallel, Salma Sakka, Fatma Meghdiche, Lamia Mbarek, Mariem Dammak, Chokri Mhiri, Khadija Maalla, Dhaker Turki |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Tunisia Adolescent Genotype Polymorphism Single Nucleotide Biochemistry Gastroenterology Young Adult 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Polymorphism (computer science) Internal medicine medicine Factor V Leiden Humans Genetic Predisposition to Disease Stroke Methylenetetrahydrofolate Reductase (NADPH2) Ischemic Stroke biology business.industry Factor V Odds ratio Middle Aged medicine.disease digestive system diseases 030104 developmental biology Methylenetetrahydrofolate reductase Mutation biology.protein Prothrombin G20210A Female Prothrombin Neurology (clinical) Gene polymorphism business 030217 neurology & neurosurgery |
| Zdroj: | Metabolic Brain Disease. 36:421-428 |
| ISSN: | 1573-7365 0885-7490 |
| Popis: | Arterial ischemic stroke (AIS) in young adults is less common in older adults, but the underlying pathogenesis and risk factors are more multi-faceted. The role of inherited thrombophilia such as 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism, (C677T and A1298C), factor V of Leiden (FVL) polymorphism, and the prothrombin G20210A mutations remains unclear. This study aims to evaluate the role of prothrombin genetic factor in AIS among young adults in Tunisia and to assess the synergistic effect between thrombogenic mutations in the pathogenesis of AIS. In this case-control study, blood samples were collected from patients and healthy controls, all matched for age and gender. The difference between them is evaluated by using the chi-square test. The odds ratio (OR) was carried out to evaluate the associations between each polymorphism and AIS risk using a binary logistic regression model. Values were considered statistically significant when p |
| Databáze: | OpenAIRE |
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