A pilot clinical trial on a new point-of-care test for the diagnosis and fast management of urinary tract infections in the Emergency Department
| Autor: | Valeria Ferrante, Alberto Mari, Paolo Visca, Giovanni Antonini, Flavia Cristofano, Francesca Losito, Salvatore Di Somma, Valentina Cellitti, Rossella Marino, Alyexandra Arienzo, Laura Magrini, Iolanda Santino, Ottavia Stalio |
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| Přispěvatelé: | Alyexandra, Arienzo, Valentina, Cellitti, Valeria, Ferrante, Francesca, Losito, Ottavia, Stalio, Flavia, Cristofano, Rossella, Marino, Laura, Magrini, Iolanda, Santino, Alberto, Mari, Visca, Paolo, Salvatore Di, Somma, Antonini, Giovanni |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Susceptibility testing
medicine.medical_specialty business.industry medicine.drug_class Urinary system Point-of-care testing Antibiotics Diagnostic accuracy Emergency department Clinical trial Urinary tract infections (UTI) point-of-care test (POCT) Micro Biological Survey (MBS) Emergency Department Health care Medicine business Intensive care medicine |
| Popis: | Background: Urinary tract infections (UTIs) are among the most common bacterial infections occurring in both community and health care setting. Laboratory diagnosis of UTIs is attained by conventional urine culture which identifies and quantifies infecting bacteria, followed by antibiotic susceptibility testing. This approach is time consuming and requires a considerable workload. A user-friendly, automated test for rapid bacterial quantification has been developed by MBS (a spin-off of Roma Tre University, Rome, Italy) as a point-of-care test (POCT) for UTIs. The aim of this study was to perform a preliminary clinical trial of the new MBS POCT for diagnosis and management of UTIs. Methods: A prospective diagnostic accuracy evaluation study was performed in collaboration with the Emergency Department of the Azienda Ospedaliera Sant’Andrea of Rome (Italy), on 122 patients with clinically suspected UTIs. Results of the MBS POCT were compared with those of the routine tests for urine culture and antibiotic susceptibility. Results: The MBS POCT, used in the Emergency Department, provided a UTI diagnosis in < 5 hours with very high accuracy, sensitivity and specificity. However, antibiotic susceptibility evaluation provided some false resistant results, when exceedingly high concentrations of bacteria were present in urines. Conclusion: The MBS POCT represents a valuable diagnostic tool for the detection of UTI, substantially saving time and assuring comparable quality of results, ultimately facilitating the successful management of infections. As for conventional antibiotic susceptibility tests, the bacterial inoculum is critical for significance of results. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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