Blood pressure control with a single-pill combination of indapamide sustained-release and amlodipine in patients with hypertension: the EFFICIENT study

Autor: Jagdish Hiremath, Uday Jadhav, Vinod K. Gujral, Michel E. Safar, Mohammad Siraj, Kamlakar Tripathi, Paramesh Shamanna, Deepak J. Namjoshi
Rok vydání: 2013
Předmět:
Male
Epidemiology
medicine.medical_treatment
lcsh:Medicine
Blood Pressure
Pharmacology
Essential hypertension
Vascular Medicine
Medicine and Health Sciences
lcsh:Science
education.field_of_study
Multidisciplinary
Indapamide
Middle Aged
Drug Combinations
Tolerability
Research Design
Hypertension
Aortic pressure
Female
Essential Hypertension
Anatomy
medicine.drug
Research Article
Adult
medicine.medical_specialty
Drug Research and Development
Clinical Research Design
Population
Urology
Cardiology
Research and Analysis Methods
medicine
Humans
Clinical Trials
Amlodipine
education
Antihypertensive Agents
Cardiovascular Disease Epidemiology
Population Biology
business.industry
Pharmacoepidemiology
lcsh:R
Biology and Life Sciences
medicine.disease
Blood pressure
Delayed-Action Preparations
Cardiovascular Anatomy
lcsh:Q
Diuretic
Clinical Medicine
business
Zdroj: PLoS ONE
PLoS ONE, Vol 9, Iss 4, p e92955 (2014)
ISSN: 1932-6203
Popis: Objective Despite antihypertensive treatment, most hypertensive patients still have high blood pressure (BP), notably high systolic blood pressure (SBP). The EFFICIENT study examines the efficacy and acceptability of a single-pill combination of sustained-release (SR) indapamide, a thiazide-like diuretic, and amlodipine, a calcium channel blocker (CCB), in the management of hypertension. Methods Patients who were previously uncontrolled on CCB monotherapy (BP≥140/90 mm Hg) or were previously untreated with grade 2 or 3 essential hypertension (BP≥160/100 mm Hg) received a single-pill combination tablet containing indapamide SR 1.5 mg and amlodipine 5 mg daily for 45 days, in this multicenter prospective phase 4 study. The primary outcome was mean change in BP from baseline; percentage of patients achieving BP control (BP
Databáze: OpenAIRE
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