Effect of aortic taper on patterns of blood flow and wall shear stress in rabbits: Association with age
| Autor: | Véronique Peiffer, Peter D. Weinberg, Ethan M. Rowland, Stephanie G. Cremers, Spencer J. Sherwin |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Aortic arch
Aging Aortic Diseases Hemodynamics Aorta Thoracic 030204 cardiovascular system & hematology Corrosion Casting Lesion 03 medical and health sciences 0302 clinical medicine medicine.artery Shear stress medicine Animals Computer Simulation 030304 developmental biology 0303 health sciences Aorta Chemistry Age Factors Models Cardiovascular X-Ray Microtomography Anatomy Blood flow Atherosclerosis Biomechanical Phenomena Shear (geology) Regional Blood Flow Descending aorta Hydrodynamics cardiovascular system Rabbits Stress Mechanical medicine.symptom Cardiology and Cardiovascular Medicine Blood Flow Velocity |
| Zdroj: | Atherosclerosis. 223:114-121 |
| ISSN: | 0021-9150 |
| Popis: | Objective The distribution of atherosclerotic lesions changes with age in human and rabbit aortas. We investigated if this can be explained by changes in patterns of blood flow and wall shear stress. Methods The luminal geometry of thoracic aortas from immature and mature rabbits was obtained by micro-CT of vascular corrosion casts. Blood flow was computed and average maps of wall shear stress were derived. Results The branch anatomy of the aortic arch varied widely between animals. Wall shear was increased downstream and to a lesser extent upstream of intercostal branch ostia, and a stripe of high shear was located on the dorsal descending aortic wall. The stripe was associated with two vortices generated by aortic arch curvature; their persistence into the descending aorta depended on aortic taper and was more pronounced in mature geometries. These results were not sensitive to the modelling assumptions. Conclusions Blood flow characteristics in the rabbit aorta were affected by the degree of taper, which tends to increase with age in the aortic arch and strengthens secondary flows into the descending aorta. Previously-observed lesion distributions correlated better with high than low shear, and age-related changes around branch ostia were not explained by the flow patterns. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect