Sharing of Endogenous Lentiviral Gene Fragments among Leporid Lineages Separated for More than 12 Million Years
| Autor: | Joana Abrantes, W. van der Loo, Pedro J. Esteves |
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| Rok vydání: | 2009 |
| Předmět: |
Genes
Viral Lineage (evolution) Molecular Sequence Data Immunology Gene Products gag Endogenous retrovirus Microbiology Genome Evolution Molecular Phylogenetics Virology biology.domesticated_animal Animals Gene Phylogeny Genetics biology Endogenous Retroviruses Lentivirus myr Lagomorpha Sequence Analysis DNA biology.organism_classification Genetic Diversity and Evolution Insect Science European rabbit |
| Zdroj: | Journal of Virology. 83:2386-2388 |
| ISSN: | 1098-5514 0022-538X |
| Popis: | Lentiviruses are causal agents of severe pathologies of a variety of mammals, including cattle and humans (e.g., AIDS and different types of lymphoma). While endogenous forms of lentivirus do not occur in these species, A. Katzourakis and coworkers (A. Katzourakis, M. Tristem, O. G. Pybus, and R. J. Gifford, Proc. Natl. Acad. Sci. USA 104:6261-6265, 2007) recently reported the presence in the genome of the European rabbit ( Oryctolagus cuniculus ) of multiple sequences defining a lentiviral subgroup elegantly referred to as RELIK ( r abbit e ndogenous l ent i virus type K ). Sequence comparisons indicated that the RELIK ancestor may have integrated into the rabbit lineage more than 7 million years ago. We have substantiated this by producing sequence data certifying the sharing of RELIK sequences among leporid lineages that diverged some 12 million years ago. |
| Databáze: | OpenAIRE |
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