Mild to moderate COVID-19 illness in adult outpatients: Characteristics, symptoms, and outcomes in the first 4 weeks of illness
| Autor: | Fangfang Wang, Holenarasipur R Vikram, Avinash Vikram, M. Teresa Seville, Juan Gea-Banacloche, Amy E Kole, Robert Orenstein, Janis E. Blair, Helen C Bartels, Syeda A. Mina, Ashwini Gotimukul, Skye A. Buckner Petty, Mark W. Burns |
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| Rok vydání: | 2021 |
| Předmět: |
myalgia
Adult Male Pediatrics medicine.medical_specialty Chest Pain Adolescent Fever Anosmia Observational Study coronavirus infections/diagnosis/drug therapy/prevention & control Chest pain Severity of Illness Index 03 medical and health sciences Young Adult 0302 clinical medicine Ambulatory care Severity of illness medicine Ambulatory Care Humans 030212 general & internal medicine Young adult Fatigue Aged Retrospective Studies Aged 80 and over business.industry SARS-CoV-2 COVID-19 Retrospective cohort study General Medicine Emergency department Myalgia Middle Aged Dyspnea Treatment Outcome Cough 030220 oncology & carcinogenesis outpatient Female medicine.symptom business Emergency Service Hospital Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 |
| Popis: | Most patients with coronavirus disease 2019 (COVID-19) have mild to moderate illness not requiring hospitalization. However, no study has detailed the evolution of symptoms in the first month of illness.At our institution, we conducted remote (telephone and video) visits for all adult outpatients diagnosed with COVID-19 within 24âh of a positive nasopharyngeal polymerase chain test for SARS-CoV-2. We repeated regular video visits at 7, 14, and 28 days after the positive test, retrospectively reviewed the prospective data collected in the remote visits, and constructed a week by week profile of clinical illness, through week 4 of illness.We reviewed the courses of 458 symptomatic patients diagnosed between March 12, 2020, and June 22, 2020, and characterized their weekly courses. Common initial symptoms included fever, headache, cough, and chest pain, which frequently persisted through week 3 or longer. Upper respiratory or gastrointestinal symptoms were much shorter lived, present primarily in week 1. Anosmia/ageusia peaked in weeks 2 to 3. Emergency department visits were frequent, with 128 visits in the 423 patients who were not hospitalized and 48 visits among the 35 outpatients (7.6%) who were eventually hospitalized (2 subsequently died). By the fourth week, 28.9% said their illness had completely resolved. After the 4-week follow up, 20 (4.7%) of the 423 nonhospitalized patients had further medical evaluation and management for subacute or chronic COVID-19 symptoms.Mild to moderate outpatient COVID-19 is a prolonged illness, with evolving symptoms commonly lasting into the fourth week of illness. |
| Databáze: | OpenAIRE |
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