CREB transcription in the medial prefrontal cortex regulates the formation of long-term associative recognition memory
| Autor: | E. C. Warburton, James B. Uney, Gareth R.I. Barker, Liang-Fong Wong |
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| Rok vydání: | 2020 |
| Předmět: |
Male
CAMP Responsive Element Binding Protein Memory Long-Term Transcription Genetic Cognitive Neuroscience Spatial ability Prefrontal Cortex Biology CREB Association 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Transcription (biology) Animals Phosphorylation Prefrontal cortex Spatial Memory Recognition memory Behavior Animal Long-term memory Research Recognition Psychology Dependovirus CREB-Binding Protein Rats Neuropsychology and Physiological Psychology biology.protein Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Barker, G R, Wong, L F, Uney, J B & Warburton, E C 2020, ' CREB transcription in the medial prefrontal cortex regulates the formation of long-term associative recognition memory ', Learning and Memory, vol. 27, no. 2, pp. 45-51 . https://doi.org/10.1101/lm.050021.119 Learn Mem |
| ISSN: | 1549-5485 |
| Popis: | The medial prefrontal cortex (mPFC) is known to be critical for specific forms of long-term recognition memory, however the cellular mechanisms in the mPFC that underpin memory maintenance have not been well characterized. This study examined the importance of phosphorylation of cAMP responsive element binding protein (CREB) in the mPFC for different forms of long-term recognition memory in the rat. Adenoviral transduction of the mPFC with a dominant-negative inhibitor of CREB impaired object-in-place memory following a 6 or 24 h retention delay, but no impairment was observed following delays of 5 min or 3 h. Long-term object temporal order memory and spatial temporal order memory was also impaired. In contrast, there were no impairments in novel object recognition or object location memory. These results establish, for the first time, the importance of CREB phosphorylation within the mPFC for memory of associative and temporal information crucial to recognition. |
| Databáze: | OpenAIRE |
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