Effect of ozone on metabolic activities of rat hepatocytes and mouse peritoneal macrophage
| Autor: | Lars Oberg, John Brian Mudd, Carl Inman, Robert Edwin Peters |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
Cell Survival Metabolite Dehydrogenase Biology Toxicology chemistry.chemical_compound Mice Ozone medicine Macrophage Animals Macrophages Glucose transporter Glyceraldehyde-3-Phosphate Dehydrogenases Lipid metabolism General Medicine Glutathione Lipids Rats medicine.anatomical_structure Glucose chemistry Biochemistry Liver Hepatocyte Toxicity Ca(2+) Mg(2+)-ATPase Peritoneum Sodium-Potassium-Exchanging ATPase |
| Zdroj: | Toxicology letters. 69(1) |
| ISSN: | 0378-4274 |
| Popis: | Peritoneal macrophage from mice and isolated hepatocytes from rats were exposed to ozone. Ozone dosages were expressed as 0–5 nmol 10 6 cells. Measurements were made of viability, glucose transport, glutathione, glyceraldehyde-3-phosphate dehydrogenase, Mg-ATPase, Na/K-ATPase, and lipid synthesis. The most sensitive parameter was glyceraldehyde-3-phosphate dehydrogenase in the peritoneal macrophage. In hepatocytes both lipid synthesis and glyceraldehyde-3-phosphate dehydrogenase were sensitive to ozone. Effects on viability, glucose transport, Mg-ATPase, and Na/K-ATPase were small to negligible in both cell types. |
| Databáze: | OpenAIRE |
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