Nephroprotective Effect of the Virgin Olive Oil Polyphenol Hydroxytyrosol in Type 1-like Experimental Diabetes Mellitus: Relationships with Its Antioxidant Effect
| Autor: | M. M. Arrebola, José Pedro De La Cruz, Juan Antonio López-Villodres, María Dolores Rodríguez-Pérez, Esther Martín-Aurioles, África Fernández-Prior, José Antonio González-Correa, Alejandra Bermúdez-Oria, María Carmen Ríos |
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| Přispěvatelé: | Junta de Andalucía, Ministerio de Economía y Competitividad (España), [Rodríguez-Pérez,MD, De La Cruz,JP, González-Correa,JA] Department of Pharmacology, Faculty of Medicine, Biomedical Research Institute (IBIMA), University of Malaga, Málaga, Spain. [López-Villodres,JA, Ríos,MC] Area of Human Histology, Faculty of Medicine, University of Malaga, Málaga, Spain. [Arrebola,MM] Clinical Laboratory, Clinical Management Unit, Hospital Axarquía, AGSEMA, Málaga, Spain. [Martín-Aurioles,E] Clinical Management Unit La Roca, Distrito Sanitario, AGSEMA, Málaga, Spain. [Fernández-Prior,A, Bermúdez-Oria,A] Department of Food Phytochemistry, Instituto de la Grasa (Spanish National Research Council, CSIC), Seville, Spain., This study was supported in part by the Consejería de Salud. Junta de Andalucía (Spain), Proyectos de Investigación en Salud (Regional Ministry of Health. Junta de Andalucía (Spain), Health Research Projects) (PI-0129-2017) and by Ministerio de Economía y Competitividad (Ministry of Economy and Competitiveness) (Spain), Centro para el Desarrollo Tecnológico Industrial (Center for the Development of Industrial Technology), FEDER Interconecta Pluri-Regional Program (Spain), (PS17173. NUTRADAF, ITC-20161265). |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Antioxidant
Anatomy::Urogenital System::Urinary Tract::Kidney [Medical Subject Headings] Physiology Thromboxane medicine.medical_treatment Clinical Biochemistry Pharmacology Biochemistry chemistry.chemical_compound Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidants [Medical Subject Headings] Analytical Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Models Theoretical [Medical Subject Headings] Diabetes mellitus Oral administration Virgin olive oil Organisms::Eukaryota::Animals [Medical Subject Headings] Hydroxytyrosol Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress [Medical Subject Headings] Analytical Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Administration Routes::Administration Oral [Medical Subject Headings] Diabetes Estrés oxidativo Eicosanoides Aceite de oliva Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus Experimental [Medical Subject Headings] Proteinuria Creatinine Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds 1-Ring::Azoles::Imidazoles::Creatinine [Medical Subject Headings] Creatinina Renal function RM1-950 Article Nephropathy medicine Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus Type 1 [Medical Subject Headings] Molecular Biology Tromboxanos Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids Unsaturated::Eicosanoids [Medical Subject Headings] business.industry Glomerulosclerosis Chemicals and Drugs::Organic Chemicals::Nitroso Compounds::Nitrosourea Compounds::Streptozocin [Medical Subject Headings] Cell Biology medicine.disease Diseases::Male Urogenital Diseases::Urologic Diseases::Urination Disorders::Proteinuria [Medical Subject Headings] Nefropatías diabéticas Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Rats [Medical Subject Headings] chemistry Oxidative stress Eicosanoids Therapeutics. Pharmacology business Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids Unsaturated::Eicosanoids::Thromboxanes [Medical Subject Headings] |
| Zdroj: | Antioxidants, Vol 10, Iss 1783, p 1783 (2021) Digital.CSIC. Repositorio Institucional del CSIC instname Antioxidants Volume 10 Issue 11 |
| Popis: | 13 Páginas.-- 3 Figuras.-- 3 Tablas The aim of this study was to determine whether hydroxytyrosol administration prevented kidney damage in an experimental model of type 1 diabetes mellitus in rats. Hydroxytyrosol was administered to streptozotocin-diabetic rats: 1 and 5 mg/kg/day p.o. for two months. After hydroxytyrosol administration, proteinuria was significantly reduced (67-73%), calculated creatinine clearance was significantly increased (26-38%), and the glomerular volume and glomerulosclerosis index were decreased (20-30%). Hydroxytyrosol reduced oxidative and nitrosative stress variables and thromboxane metabolite production. Statistical correlations were found between biochemical and kidney function variables. Oral administration of 1 and 5 mg/kg/day of hydroxytyrosol produced an antioxidant and nephroprotective effect in an experimental model of type 1-like diabetes mellitus. The nephroprotective effect was significantly associated with the systemic and renal antioxidant action of hydroxytyrosol, which also influenced eicosanoid production. This study was supported in part by the Consejería de Salud. Junta de Andalucía (Spain), Proyectos de Investigación en Salud (Regional Ministry of Health. Junta de Andalucía (Spain), Health Research Projects) (PI-0129-2017) and by Ministerio de Economía y Competitividad (Ministry of Economy and Competitiveness) (Spain), Centro para el Desarrollo Tecnológico Industrial (Center for the Development of Industrial Technology), FEDER Interconecta Pluri-Regional Program (Spain), (PS17173. NUTRADAF, ITC-20161265). |
| Databáze: | OpenAIRE |
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