Serum levels of vitamin A and 25-hydroxyvitamin D3 (25OHD3) as reflectors of pulmonary function and quality of life (QOL) in children with stable asthma
| Autor: | Ya-Jie Bai, Ru-Jun Dai |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Vitamin Pediatrics medicine.medical_specialty Vital Capacity vitamin A Pulmonary function testing 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Quality of life Predictive Value of Tests Forced Expiratory Volume Activities of Daily Living activity of daily living medicine Vitamin D and neurology Humans Vitamin D Child Lung Asthma business.industry 25-hydroxyvitamin D3 pulmonary function Case-control study Clinical Trial/Experimental Study General Medicine respiratory system medicine.disease Respiratory Function Tests respiratory tract diseases 030104 developmental biology medicine.anatomical_structure quality of life 030228 respiratory system chemistry Case-Control Studies Predictive value of tests Female stable asthma business Biomarkers circulatory and respiratory physiology Research Article |
| Zdroj: | Medicine |
| ISSN: | 0025-7974 |
| Popis: | Background: This study aims to explore the relationship between serum vitamin A and 25-hydroxyvitamin D3 (25OHD3) levels with pulmonary function and quality of life (QOL) in children with stable asthma. Methods: A total of 117 cases of children with stable asthma were assigned into the case group and 129 healthy children underwent physical examination during the same period into the control group. Electrochemiluminescence was employed to determine serum vitamin A and 25OHD3 levels. The children with stable asthma were further divided into the mild, moderate, and severe groups according to their degree of asthma. A pulmonary function meter was used to assess the pulmonary function indexes: percentage of forced expiratory volume in 1 sec/predictive value (FEV1%pred), forced vital capacity (FVC), forced expiratory volume in 1 sec/forced vital capacity (FEV1/FVC), peak expiratory flow (PEF), and maximal voluntary ventilation (MVV). The children's quality (QOL) of life with asthma was evaluated by their activities of daily living (ADLs) and Medical Research Council (MRC) scores. Pearson correlation analysis was applied to analyze the correlations of serum vitamin A and 25OHD3 levels with FEV1%pred, FVC, FEV1/FVC, PEF, MVV, ADL, and MRC. Results: Serum vitamin A and 25OHD3 levels were lower in children with stable asthma than those who were in the control group (P |
| Databáze: | OpenAIRE |
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