Preventing Intolerance: The Induction of Nonresponsiveness to Dietary and Microbial Antigens in the Intestinal Mucosa
| Autor: | Donald W. Smith, Cathryn Nagler-Anderson |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Antigens
Bacterial Flora Immunology Receptors Cell Surface Pathogenic bacteria Dendritic Cells Biology Immune dysregulation medicine.disease_cause Microbiology Lymphatic system medicine.anatomical_structure Antigen Intestinal mucosa Tissue damage Immune Tolerance medicine Humans Immunology and Allergy Intestinal Mucosa Food Hypersensitivity B cell |
| Zdroj: | The Journal of Immunology. 174:3851-3857 |
| ISSN: | 1550-6606 0022-1767 |
| DOI: | 10.4049/jimmunol.174.7.3851 |
| Popis: | The gut-associated lymphoid tissue (GALT) is constantly exposed to a variety of Ags and must therefore decipher a large number of distinct signals at all times. Responding correctly to each set of signals is crucial. When the GALT receives signals from the intestinal flora or food Ags, it must induce a state of nonresponsiveness (mucosal tolerance). In contrast, when pathogenic bacteria invade the intestinal mucosa, it is necessary to elicit strong T and B cell responses. The GALT is therefore in the position of constantly fighting intolerance to food and the commensal flora while effectively battling infectious microbes. Determining precisely which type of response to generate in each case is key to the prevention of immune dysregulation and tissue damage. |
| Databáze: | OpenAIRE |
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