Physicochemical, setting, rheological, and mechanical properties of a novel bio-composite based on apatite cement, bioactive glass, and alginate hydrogel

Autor: H. Ben youcef, Hassan Noukrati, Bertrand Lefeuvre, H. Mabroum, Hassane Oudadesse, Allal Barroug
Přispěvatelé: Université Cadi Ayyad [Marrakech] (UCA), Université Mohammed VI Polytechnique [Ben Guerir] (UM6P), Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), OCP group (Morocco) through the APPHOS Program [MAT-BAR-01/2017], Mohammed VI Polytechnic University [Marocco] (UM6P), Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Université de Rennes (UNIV-RENNES)-Institut National des Sciences Appliquées (INSA)
Rok vydání: 2021
Předmět:
Zdroj: Ceramics International
Ceramics International, 2021, 47 (17), pp.23973-23983. ⟨10.1016/j.ceramint.2021.05.106⟩
Ceramics International, Elsevier, 2021, 47 (17), pp.23973-23983. ⟨10.1016/j.ceramint.2021.05.106⟩
ISSN: 0272-8842
DOI: 10.1016/j.ceramint.2021.05.106
Popis: International audience; Calcium phosphate cements (CPC) have been widely investigated as bone substitutes, owing to their attractive features in terms of physicochemical and biocompatibility properties. However, the clinical applicability of this group of biomaterials is still critically limited by its poor strength and rheological properties in terms of injectability and cohesion. The present work aims to develop novel composite cement based on calcium phosphate cement (CPC) and bioactive glass (BG), associated with sodium alginate hydrogel (Alg). The composition, microstructure, setting, rheological, and mechanical properties of this composite cement were further investigated. Evaluation of setting properties showed that BG participates crucially in the setting reaction as a calcium and phosphate provider and serves as a setting accelerator. Thus, the setting time appears lower in these cements than in the reference CPC cement: it decreases from 75 to 42 min as the BG content increases from 10 to 25 wt% and is delayed from 42 to 73 min while the Alg amount augmented from 1 to 5 wt%. The rheological evaluation revealed that injectability was slightly improved with increasing BG content compared to the injectability of CPC, reaching a value close to 100% when combined with Alg hydrogel. The anti-washout property appeared to be weak for the CPC with or without BG, which are disintegrated in solution. The cohesiveness was significantly improved by introducing Alg hydrogel; furthermore, the addition of 5 wt% of alginate hydrogel induced an increase in the compressive strength about twice (7.2 MPa) higher than that of the reference CPC (4.0 MPa). According to the above findings, the addition of BG acts as a setting accelerator leading to a fast apatite formation, while the introduction of Alg hydrogel as a rheological promoting agent improves the injectability and cohesion. The combination of BG and Alg as additives increased the compressive strength compared to the reference cement.
Databáze: OpenAIRE
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