Formulation design and evaluation of Cefuroxime axetil 125 mg immediate release tablets using different concentration of sodium lauryl sulphate as solubility enhancer
| Autor: | Syed Muhammad Farid Hasan, Fozia Israr, Fouzia Hassan, Shazia Naz, Sabahat Jabeen, Lubna Bashir, Zafar Alam Mahmood |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
integumentary system
Chemistry Sodium lauryl sulphate Direct compression lcsh:RS1-441 Cefuroxima axetil/comprimidos de liberação imediata/propriedades físico-mecânicas Lauril sulfato de sódio lcsh:Pharmacy and materia medica Compressão direta medicine Cefuroxime axetil/immediate release tablets/physico-mechanical properties Immediate release Solubility Cefuroxime medicine.drug Nuclear chemistry |
| Zdroj: | Brazilian Journal of Pharmaceutical Sciences, Vol 50, Iss 4, Pp 943-953 (2014) Brazilian Journal of Pharmaceutical Sciences; Vol. 50 No. 4 (2014); 943-953 Brazilian Journal of Pharmaceutical Sciences; Vol. 50 Núm. 4 (2014); 943-953 Brazilian Journal of Pharmaceutical Sciences; v. 50 n. 4 (2014); 943-953 Brazilian Journal of Pharmaceutical Sciences Universidade de São Paulo (USP) instacron:USP Brazilian Journal of Pharmaceutical Sciences, Volume: 50, Issue: 4, Pages: 943-953, Published: DEC 2014 |
| ISSN: | 2175-9790 1984-8250 |
| Popis: | Cefuroxime axetil immediate release tablets were formulated by direct compression method with different percentages of sodium lauryl sulphate (SLS) such as 0.5, 1.0, 1.5 and also without SLS. Resulting batches of tablets were evaluated by both pharmacopeial and non-pharmacopeial methods to ascertain the physico-mechanical properties. Dissolution test were carried out in different medium like 0.07 M HCl, distilled water, 0.1M HCl of pH 1.2 and phosphate buffers at pH 4.5 and 6.8 to observe the drug release against the respective concentration of SLS used. Later, test formulations were compared by f1(dissimilarity) and f2(similarity) factors using a reference brand of cefuroxime axetil. Significant differences (p |
| Databáze: | OpenAIRE |
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