Biochemical Differences Between Vitreous Humor and Cerebral Spinal Fluid in a Death From Diabetic Ketoacidosis
| Autor: | Winston Philcox, Rexson Tse, Jack Garland, Toni OʼRegan, Kilak Kesha, Sinead McCarthy, Simon Stables, Leo Lam, Cristian Palmiere |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Pathology medicine.medical_specialty Diabetic ketoacidosis CSF glucose Autopsy Ventricular system Pathology and Forensic Medicine Ancillary test Diabetic Ketoacidosis 03 medical and health sciences Young Adult 0302 clinical medicine Cerebrospinal fluid Fatal Outcome Medicine Humans 030216 legal & forensic medicine medicine.diagnostic_test 3-Hydroxybutyric Acid business.industry Cerebral Spinal Fluid Lumbar puncture medicine.disease Vitreous Body Glucose business |
| Zdroj: | The American journal of forensic medicine and pathology. 40(2) |
| ISSN: | 1533-404X |
| Popis: | Biochemical analysis of cerebrospinal fluid (CSF) and vitreous humor (VH) forms an important diagnostic ancillary test at autopsy. Cerebrospinal fluid can be sampled from the ventricular system (VA) and from lumbar puncture (LP), whereas VH can be sampled from the orbits. Biochemical electrolytes seem to vary between VH and CSF collected from different sites, but whether there is any difference in glucose and β-hydroxybutyrate is unclear. We present a case report of a 21-year-old man who died of diabetic ketoacidosis confirmed at autopsy. Ventricular system, LP, and VH were biochemically analyzed and showed that glucose was highest in VH (41 mmol/L) and was 6 and 8 mmol/L higher than CSF in the LP and VA, respectively. β-Hydroxybutyrate was also highest in VH (20 mmol/L) and was 5 and 6 mmol/L higher than LP and VA, respectively. Our findings suggest that postmortem CSF glucose and β-hydroxybutyrate may not truly reflect that of VH and vary between CSF sampling sites. |
| Databáze: | OpenAIRE |
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